摘要
目的探讨血栓前状态易感基因变异与复发性流产的相关性.方法选择2021-12至2023-12在解放军总医院第九医学中心就诊的复发性流产患者103例,并选择同期就诊的无自然流产史患者91例作为对照.分别对两组人群的血栓前状态易感基因变异进行检测,包括FVL基因1691位点、FⅡ基因20210位点、PAI-1基因675位点、MTHFR基因677位点和1298位点.结果两组FVL基因1691位点、FⅡ基因20210位点均未见杂合变异与纯合变异;两组间PAI-1基因675位点变异(χ^(2)=0.429,P=0.452)、MTHFR基因677位点(χ^(2)=1.346,P=0.510)和1298位点(χ^(2)=2.866,P=0.245)基因变异频率无统计学差异.单因素回归分析显示,PAI-1基因675位点(OR=1.245,95%CI:0.624~2.482,P=0.533),MTHFR基因677位点(OR=1.071,95%CI:0.571~2.009,P=0.830)和1298位点(OR=1.6324,95%CI:0.883~3.017,P=0.117)的基因变异与复发性流产无关.结论FVL基因、FⅡ基因、PAI-1基因及MTHFR基因变异与复发性流产无相关性,不建议此类患者常规进行遗传性血栓前状态检测.
Objective To explore the association between prethrombotic state susceptibility gene variation and recurrent abortion.Methods A total of 103 patients with recurrent abortion from the Ninth Medical Center of PLA General Hospital from December 2021 to December 2023,and 91 patients with no history of spontaneous abortion were selected as controls.Prethrombotic susceptibility gene variants were detected in the two groups,including FVL gene 1691 locus,FⅡgene 20210 locus,PAI-1 gene 675 locus,MTHFR gene 677 locus and 1298 locus.Results Neither heterozygous nor homozygous variation were detected at locus 1691 of the FVL gene or locus 20210 of FⅡgene in the two groups.Additionally,no significant differences in mutation frequencies were found between the two groups at locus 675 of the PAI-1 gene(χ^(2)=0.429,P=0.452),locus 677 of the MTHFR gene(χ^(2)=1.346,P=0.510),and locus 1298 of the MTHFR gene(χ^(2)=2.866,P=0.245).Univariate regression analysis indicated that no association between the occurrence of recurrent spontaneous abortion and the frequencies of mutations in the PAI-1 gene at locus 675(OR=1.245,95%CI:0.624~2.482,P=0.533),the MTHFR gene at locus 677(OR=1.071,95%CI:0.571~2.009,P=0.830),and locus 1298(OR=1.6324,95%CI:0.883~3.017,P=0.117).Conclusions Variations of FVL gene,FⅡgene,PAI-1 gene and MTHFR gene are not associated with recurrent abortion,and should not be screened for patients of recurrent abortion.
作者
王敏
潘菀淳
张和平
王鑫
孙婷玉
周玲
WANG Min;PAN Wanchun;ZHANG Heping;WANG Xin;SUN Tingyu;ZHOU Ling(Department of Obstetrics and Gynecology,the Ninth Medical Center of PLA General Hospital,Beijing 100101,China)
出处
《武警医学》
CAS
2024年第8期703-706,共4页
Medical Journal of the Chinese People's Armed Police Force
基金
军队某课题资助
作者简介
王敏,博士,副主任医师;通讯作者:周玲,E-mail:icepear@hotmail.com
