摘要
The increasing global aging population has led to a continual rise in the prevalence of bone and joint diseases,posing challenges to both the quality of life for patients and healthcare resources.Type Ⅱ collagen,a pivotal protein for sus-taining joint function,has gained substantial attention in recent years.The oral administration of undenatured type Ⅱcollagen(UC-Ⅱ)has demonstrated noteworthy advancements in tackling bone and joint diseases.This article presents a comprehensive review of the structure and extraction methods of UC-Ⅱ,discusses the relationship between UC-Ⅱand arthritis,and thoroughly examines its therapeutic role and potential mechanisms in the treatment process.In addition,future perspectives for clinical application of UC-Ⅱ are discussed.It was found that the oral administration of UC-Ⅱ,through induction of oral tolerance mechanisms,exhibits promise in alleviating joint inflammation and pain in patients with osteoarthritis(OA)and rheumatoid arthritis(RA).This method can significantly ameliorate joint inflammation and pain,with high patient acceptance and minimal side effects,demonstrating its potential as a well-tolerated treatment option for joint diseases.
基金
funded by National Natural Science Foundation of China(32101980)
Natural Science Foundation of Chongqing(CSTB2023NSCQMSX0304)
Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202100225)
National Center of Technology Innovation for Pigs(NCTIP-XD/B02)
Innovation Training Program for College Students at Southwest University(202310635054).
作者简介
Correspondence:Yu Fu,fuy987@swu.edu.cn,fuy987@hotmail.com.
