摘要
目的:分析血清巨噬细胞炎性蛋白(MIP)-1α、白细胞介素(IL)-17A水平与肺癌患者临床病理特征的相关性.方法:回顾性分析2017年1月至2020年6月内黄县人民医院收治的120例肺癌患者临床资料,全部患者经胸腔镜肺癌根治术治疗,术中记录患者临床病理特征,检测入选者血清MIP-1α、IL-17A水平,分析血清MIP-1α、IL-17A水平与肺癌患者临床病理特征的相关性.结果:120例肺癌患者中,病理类型为鳞癌的有46例,发生淋巴结转移85例,TNM分期Ⅲ期有55例.不同病理类型、TNM分期患者的血清MIP-1α、IL-17A水平比较,差异无统计学意义(P>0.05),发生淋巴结转移患者血清MIP-1α、IL-17A水平均高于未发生淋巴结转移患者,差异有统计学意义(P<0.05).经Logistics回归分析显示,血清MIP-1α、IL-17A水平升高是肺癌患者发生淋巴结转移的风险因子(OR>1,P<0.05).结论:MIP-1α、IL-17A可能参与肺癌患者的淋巴结转移,与肺癌的临床病理特征具有相关性.
Objective:To analyze the correlation between serum macrophage inflammatory protein-1α(MIP-1α)and interleukin-17A(IL-17A)levels and clinicopathological features of patients with lung cancer.Methods:The clinical data of 120 patients with lung cancer admitted to Neihuang County people's Hospital from January 2017 to June 2020 were retrospectively analyzed.All patients underwent thoracoscopic radical resection of lung cancer for treatment,the clinicopathological features of patients during operation were recorded,serum MIP-1αand II-17A levels of selected patients were detected,the correlation between serum MIP-1α,IL-17A levels and clinicopathological features of patients with lung cancer was analyzed.Results:Among 120 cases of patients with lung cancer,46 casey were squamous cell carcinoma,85 cases were lymph node metastasis,and 55 cases were TNM stage III.Compared the levels of serum MIP-1α and IL-17A among patients with different pathological types and TNM stages,there was no statistical significant difference(P>0.05),the serum MIP-1αand IL-17A levels in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,there was a statistical significant difference(P<0.05).Logistic regression showed that the increased serum MIP-1αand IL-17A levels were risk factors for lymph node metastasis in patients with lung cancer(OR>1,P<0.05).Conclusion:MIP-1α and IL-17A may be involved in lymph node metastasis in patients with lung cancer,which is correlated with clinicopathological features.
作者
李文明
LI Wen-ming(Department of Medical Laboratory,Neihuang County People's Hospital,Anyang 456300,China)
出处
《四川解剖学杂志》
2021年第4期28-30,共3页
Sichuan Journal of Anatomy
作者简介
李文明,医学检验主管技师,本科学历,研究方向:医学检验,e-Mail:838459390@qq.com
