摘要
Menopause is a biological event associated with the complete cessation of a woman’s reproductive ability.Early menopause is defined as entry into menopause between the ages of 40 and 45 years,and has a significant impact on the fertility of affected women.Early menopause is a complex and heterogeneous disorder that is influenced by multiple genetic and environmental factors,as well as the interactions between these factors.Genome-wide association study(GWAS)is a novel strategy that has recently come into use as a way to overcome the limitations of genome-wide linkage analyses and candidate gene association approaches to discover novel susceptibility loci for early menopause.GWAS has identified many new candidate genes or loci associated with early menopause.In this review,we provide an overview of the current understanding of the genetic factors associated with early menopause that have been identified by GWAS.We also discuss potential approaches that could be used in the future to identify new genes associated with early menopause.
基金
supported by the grants from the National Key Research and Development Program of China(2016YFC1000500)
the National Natural Science Foundation of China(81430005,31521003)
the Commission for Science and Technology of Shanghai Municipality(13JC1407600)
作者简介
Corresponding author:Xiaojin Zhang,Obstetrics and Gynecology Hospital,Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Fudan University,Shanghai 200011,China.E-mail:zxjgcp@126.com.
