摘要
Background:The prevalence rates of freezing of gait(FOG)in Parkinson’s disease(PD)vary widely,ranging from 14.0 to 55.1%.Our aim is to calculate the overall prevalence of FOG in all PD patients with different disease durations and severities.Methods:Using Medline/PubMed/Embase,we carried out a systematic literature search for studies reporting the PD and clinically relevant FOG.Results:After primary screening,a total of 35 studies were identified and further analyzed for inclusion into the analysis,and 29 studies fulfilled the quality criteria and included in this meta-analysis.The overall prevalence of FOG in PD was 39.9%(95%CI 35.3-44.5%).The FOG identified by the freezing of gait questionnaire item 3 may be more prevalent(43.8%,95%CI 38.5-49.1%)than the FOG identified by the Unified Parkinson’s Disease Rating Scale item 14(36.0%,95%CI 29.0-43.1%).Disease duration and severity are both the clinical features associated with the FOG.The highest FOG prevalence rate in PD patients was seen in patients with disease durations≥10 years,at 70.8%,followed that of PD patients with disease durations≥5 years(53.3%),and PD patients with disease durations<5 years(22.4%).FOG presented in 28.4%of PD patients with Hoehn and Yahr staging(H&Y)score≤2.5,and in 68.4%of PD patients with H&Y score≥2.5.Conclusion:This meta-analysis confirms that the prevalence of FOG in PD is considerable,and highlights the need for accurate identification of FOG in PD.
作者简介
first authors:Hong-Liang Ge,contributed equally to this work;first authors:Xiao-Yong Chen contributed equally to this work;Corresponding author:Chen-Yu Ding,dingcydr@163.com
