摘要
脂肪组织不仅是能量的储存场所,也是重要的免疫器官,与多种疾病发生发展密切相关.爬行脂肪,或称为肠系膜脂肪增生,是克罗恩病(CD)的特征性病理表现之一.近年来越来越多研究表明,爬行脂肪与CD肠道炎症反应、纤维化等并发症形成密切相关,术中切除受累肠系膜脂肪甚至可明显降低CD术后复发风险.CD肠系膜脂肪的相关研究已成为炎症性肠病领域的一个学术新热点.本文将对该领域相关基础研究进行总结,分析该领域存在的研究"瓶颈",最后尝试对未来研究方向提出设想和展望.
Adipose tissue is not only an organ for energy storage,but also immune active,which is involved in pathogenesis of various human diseases.As a hallmark of Crohn's disease,creeping fat(or fat wrapping)has been reported to play an crucial role in mechanism of intestinal inflammation and fibrosis in CD.Recent studies indicated that surgical removal of involved mesenteric fat could even significantly reduce the risk of postoperative recurrence in CD.Increasing attention has been paid to the research about creeping fat in CD.This review concisely summarizes the state-to-art knowledge in creeping fat,analyzes some potential research"bottleneck",and finally proposes future outlooks in the field.
作者
林斯楠
何锦燊
陈旻湖
毛仁
Lin Sinan;He Jinshen;Chen Minhu;Mao Ren(Department of Gastroenterology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Lerner Research Institute,Cleveland Medical Center,USA)
出处
《中华炎性肠病杂志（中英文）》
2019年第4期296-300,共5页
Chinese Journal of Inflammatory Bowel Diseases
作者简介
通信作者:毛仁,Email:maoren2023@gmail.com,电话:020-87755766
