摘要
目的探讨伊立替康联合沙利度胺治疗晚期原发性肝癌的疗效及对血清高尔基Ⅱ型跨膜蛋白-73(GP-73)和磷脂酰基醇蛋白聚糖-3(GPC-3)水平的影响.方法本研究共纳入60例2011年12月-2016年12月钦州市第一人民医院收治的晚期原发性肝癌患者,按数字表法将所有患者随机分为治疗组和对照组,每组30例.对照组口服替吉奥胶囊,2次/d,连续给药28d,休息14d.治疗组在对照组基础上第1、8、15d予盐酸伊立替康注射液80mg/(m2·d)静脉滴注,1个疗程/3周;口服沙利度胺片.两组连续治疗12周,比较两组视觉模拟评分(VAS)、疼痛程度数字分级法评分(NRS)及生活质量和近期实体瘤疗效,检测两组血清GP-73和GPC3水平.结果治疗后,治疗组患者VAS、NRS评分显著少于对照组(P<0.01).治疗组患者的生活质量总改善率为83.33%,显著高于对照组(56.67%,x2=3.889,P<0.05).治疗组患者的近期实体瘤总改善率为70%,显著高于对照组(40%,x2=5.455,P<0.05).治疗后,治疗组患者血清GP-73和GPC3水平显著低于对照组(P<0.01).结论伊立替康联合沙利度胺治疗晚期原发性肝癌,可减轻患者的疼痛,提高生活质量和近期实体瘤疗效,这可能与其下调血清GP-73和GPC3水平有关.
Objective To investigate the efficacy of Irinotecan combined with thalidomide in treating later period stage of primary liver cancer and its influence on serum levels of golgi apparatus glycoprotein-73(GP-73)and glypican-3(GPC-3).Methods Sixty cases with later period stage of primary liver cancer were selected and randomly divided into control group and treatment group with 60 cases in each group.Control group was orally treated with Tegafur gimeracil oteracil potassium capsule(bid)for 28 d and has a rest for 14 d.Based on control group,treatment group was given with Irinotecan with 80 mg/(m2·d)(intravenous drip at the first,eighth,and fiteenth day and 1 course per 3 weeks),and thalidomide.Both groups were treated for twelve weeks.Scores of visual analogue score(VAS)and pain degree digital grading(NRS)and the efficacy of life quality and solid tumor were compared between two groups.Serum levels of GP-73 and GPC3 were detected in both groups.Results After treatment,scores of VAS and NRS of treatment group were obviously lower than control group(P<0.01).Total effective rate of life quality of treatment group was 83.33%,which was higher than control group(56.67%,χ2=3.889,P<0.05).Total effective rate of solid tumor of treatment group was 76.67%,which was higher than control group(53.33%,χ2=4.512,P<0.05).Serum levels of GP-73 and GPC3 of treatment group were obviously lower in the treatment group than the control after treatment(P<0.01).Conclusions Irinotecan combined with thalidomide in treating later period stage of primary liver cancer can reduce ache,increase the efficacies of life quality and recent solid tumor,which was related with decrease serum levels of GP-73 and GPC3.
作者
梁善斌
韦良鹏
Liang Shanbin;Wei Liangpeng(The First People's Hospital of Qinzhou,Qinzhou 535099,China)
出处
《中华转移性肿瘤杂志》
2019年第1期26-30,共5页
Chinese Journal of Metastatic Cancer
作者简介
通讯作者:韦良鹏,Email:lsb0050@qq.com
