摘要
目的:探索FIGO分期早期宫颈癌及局部晚期宫颈癌手术后复发患者的临床特征及复发模式的异同,以期基于证据有效进行随访及术后患者的管理及治疗。方法:收集2011—2016年在第三军医大学第一附属医院确诊并进行根治性手术和/或辅助治疗后复发转移病例165例。基于FIGO分期分为早期(107例)和局部晚期(58例)宫颈癌2个组,比较两组患者淋巴结转移情况,初次手术组织学类型、病理特征,复发时间及间隔、复发转移类型及部位(盆腔局部受累、远处受累或多部位受累)情况。结果:总计1784例宫颈癌腹腔镜手术患者,平均随访时间为60个月,术后即失访患者65例(失访率3.6%)。复发转移患者共165例(复发率9.2%)。两组患者淋巴结转移情况有差异,局部晚期高于早期宫颈癌,P<0.05。但组织学类型、肿瘤分化程度、肌层浸润及脉管癌栓均无统计学差异,P>0.05。从治疗结束到复发转移中位时间分别为16月和17月。两组间复发时间及复发类型无统计学差异,P>0.05。最常见的复发部位是盆腔中心复发。结论:本研究提示FIGO分期与复发时间及复发部位无显著的关联,早期宫颈癌及局部晚期宫颈癌的复发模式无明显差异。研究结果显示,术后2年内,需加强随访复查。
Objective:To explore the differences of the clinical features in recurrence patterns after surgery,in early and local advanced cervical cancers.We hope to provide evidence to guide follow-up and postoperative management.Methods:Cases with cervical cancer who underwent radical surgery and/or adjuvant therapy at the First Affiliated Hospital of the Third Military Medical University from January 2011 to December 2016,experienced recurrence and metastasis have been collected.The data were divided into early(107 patients)and locally advanced(58 patients)cervical cancer two groups based on FIGO stage.Retrospective a was performed to compare the two groups:the lymph node metastasis,histological type and other pathological characteristics,recurrence time and interval,recurrence and metastasis type and site(local pelvic,distant or multiple site).Results:A total of 1784 cases included,which were followed up for an average of 60 months,and 65 patients were lost to follow-up after surgery(3.6%).There were 165 patients with recurrence and metastasis(9.2%).The lymph node metastasis of early group higher than the locally advanced group,P<0.05.There was no significant difference in the clinical features between the two groups:histological type,degree of tumor differentiation,deep stromal invasion or lymphovascular space invasion cancer(P>0.05).The median time of the recurrence and metastasis was 16 or 17 months,respectively.There was no statistical difference in the recurrence time and type between the two groups(P>0.05),the frequent site of recurrence was the pelvic cavity.Conclusion:This study suggested that FIGO staging was not associated with recurrence time and space.There was no significant difference in recurrence patterns between early cervical cancer and locally advanced cervical cancer.The study showed that follow-up should be strengthened within 2 years after surgery.
作者
李宇迪
凌开建
邓黎
胡群英
陈勇
唐帅
宋斌
张文希
姚远洋
余美佳
程李娟
周丹
李真
甘华
王文婷
邓艳
王延州
梁志清
Li Yudi;Ling Kaijian;Deng Li;Hu Qunying;Chen Yong;Tang Shuai;Song Bin;Zhang Wenxi;Yao Yuanyuan;Yu Meijia;Cheng Lijuan;Zhou Dan;Li Zhen;Gan Hua;Wang Wenting;Deng Yan;Wang Yanzhou;Liang Zhiqing(Department of Obstetrics and Gynecology,The First Affiliated Southwest Hospital of Army Military Medical University,Chongqing 400038,China)
出处
《中华转移性肿瘤杂志》
2020年第4期269-273,共5页
Chinese Journal of Metastatic Cancer
基金
国家重点研发计划(2019YFC1005202、2019YFC1005204)
关键词
腹腔镜手术
早期宫颈癌
局部晚期宫颈癌
复发转移
Laparoscopic surgery
Early cervical cancer
Locally advanced cervical cancer
Recurrence and metastasis
作者简介
通信作者:梁志清,Email:Zhi_lzliang@yahoo.com
