摘要
目的探究阿戈美拉汀联合认知行为干预对缺血性脑卒中后抑郁患者的影响。方法选取2018年10月~2019年4月本医院收治的60例缺血性脑卒中后抑郁患者,采用抽签法将其平均分成2组(试验组与参照组),其中参照组运用艾司西酞普兰联合认知行为干预,试验组运用阿戈美拉汀联合认知行为干预。对两组患者治疗前后情绪情况、再发脑卒中率、神经系统毒性反应、胃肠道反应进行比较分析。结果试验组出院3个月再发脑卒中发生1例,参照组发生4例,两组无明显差异(χ~2值=1.9636,P值=0.1611),试验组出院6个月再发脑卒中2例,明显低于参照组的8例(χ~2值=4.3200,P值=0.0376);试验组神经系统毒性反应发生1(3.33%)例,明显低于参照组7(23.33%)例(χ~2值=5.1923,P值=0.0226),;试验组与参照组负面情绪在治疗前对比无明显差异P>0.05,治疗后试验组SDS与SAS评分均低于参照组(P<0.05);试验组胃肠道反应发生1(3.33%)例低于参照组6(20.00%)例(χ~2值=4.0431,P值=0.0443)。结论阿戈美拉汀联合认知行为干预可有效缓解缺血性脑卒中后抑郁患者负性情绪,降低其再发脑卒中的比率,并且神经系统毒性反应和胃肠道反应也比较轻。
Objective To investigate the clinical value of the combination of agomelatine and cognitive behavioral intervention in depression patients with post-ischemic stroke.Methods 60 patients with post-ischemic poststroke depression from October 2018 to April 2019 were selected and divided into two groups by means of lottery.The reference group used escitalopram combined with cognitive behavioral intervention,and the experimental group used agomelatine in combination with cognitive behavioral intervention.The improvement of negative emotions,the rate of recurrent stroke,the incidence of neurotoxicity,and gastrointestinal reactions before and after treatment were compared.Results There was no different on the number of recurrent stroke between two groups after 3 months discharged.The number of recurrent stroke patients in the experimental group was higher than that in reference group after 6 months discharged(P<0.05).The total incidence of neurotoxicity and gastrointestinal reactions in the experimental group were lower than those in the reference group(P<0.05).There was no significant difference on the SDS and SAS scores between the two group before the treatment,after treatment,the SDS and SAS scores in the experimental group were lower than those in the reference group(P<0.05).Conclusion The combination of agomelatine and cognitive behavioral intervention can effectively reduce depression/anxiety and the rate of recurrent stroke in depression patients with postischemic stroke,and the neurotoxicity and gastrointestinal reactions were low.
作者
王俊仙
李艳红
任帅
WANG Junxian;LI Yanhong;REN Shuai(Department Of Psychiatry,Luoyang Fifth People Hospital,Luoyang 471000,China)
出处
《国际精神病学杂志》
2020年第1期120-122,132,共4页
Journal Of International Psychiatry
作者简介
第一作者及通讯作者:王俊仙(1969.12-),女,河南洛阳人,本科,副主任医师,研究方向:精神科治疗,Email:gonglan73811@163.com。
