摘要
目的:探讨N末端脑钠肽前体(NT-proBNP)在儿童高原性心脏病合并心力衰竭病情评估中的价值。方法:收集2017年1月—2020年10月在我院收治的高原性心脏病患儿82例为高原性心脏病组,同时选取先天性心脏病患儿70例为先天性心脏病组,正常儿童70例作为健康组,检测各组血清NT-proBNP水平,并分析高原心脏病组血清NT-proBNP水平与改良小儿心衰分级评分(ROSS评分)的相关性。结果:高原性心脏病组患儿血清NT-proBNP水平为(810.20±104.43)ng/L,明显高于先天性心脏病组和健康组儿童血清NT-proBNP水平(P<0.05);高原性心脏病合并轻度、中度和重度心衰患儿血清NT-proBNP水平分别为(767.80±105.65)ng/L、(865.03±112.20)ng/L和(957.42±109.46)ng/L,明显高于无心衰患儿(P<0.05),同时重度心衰患儿血清NT-proBNP水平明显高于轻度、中度患儿(P<0.05);高原性心脏病组患儿血清NT-proBNP水平与ROSS评分呈正相关(r=0.708,P<0.05);NT-proBNP预测高原性心脏病合并心衰的ROC曲线下面积为0.820,P<0.05,截断值为848.20 ng/L,灵敏性和特异性分别为57.40%和95.24%;高原性心脏病患儿治疗后血清NT-proBNP为(320.15±98.27)ng/L,较治疗前明显降低(P<0.05)。结论:高原性心脏病患儿血清NT-proBNP水平明显升高,与心衰程度存在相关性,在预测高原性心脏病合并心力衰竭中有一定诊断价值。
Objective:This paper is aimed to investigate the value of N-terminal pro brain natriuretic peptide(NT-proBNP)in the assessment of children with high altitude heart disease and heart failure.Methods:82children with high altitude heart disease treated in our hospital from January 2017 to October 2020 were collected as the high altitude heart disease group.At the same time,70 children with congenital heart disease were selected as the congenital heart disease group and 70 normal children as the healthy group.Then we detected the serum NTproBNP level of each group,and analyzed the correlation between serum NT-proBNP levels and ROSS score in the high attitade heart disease group.Results:The serum NT-proBNP levels of children in high altitude heart disease group was(810.20±104.43)ng/L,which was significantly higher than that of children in congenital heart disease group and healthy children group(P<0.05);while the serum NT-proBNP levels in children with mild,moderate and severe heart failure were(767.80±105.65)ng/L,(865.03±112.20)ng/L and(957.42±109.46)ng/L respectively,which were significantly higher than those in children without heart failure(P<0.05).Meanwhile,the serum NT-proBNP levels in children with severe heart failure were significantly higher than those in children with mild and moderate heart failure(P<0.05).NT-proBNP was positively correlated with modified ROSS score in children in high altitude heart disease group(r=0.708,P<0.05).The area under ROC curve of NT-proBNP in predicting high altitude heart disease complicated with heart failure was 0.820,P<0.05,the cut-off value was 848.20ng/L;the sensitivity and specificity were 57.40%and 95.24%respectively.After treatment,the serum NT-proBNP level in children with high altitude heart disease was(320.15±98.27)ng/L,which was significantly lower than that before treatment(P<0.05).Conclusion:The serum NT-proBNP levels of high altitude heart disease children is significantly increased,which is related to the degree of heart failure,and it also has certain diagnostic value in predicting high altitude heart disease with heart failure.
作者
谢雨桐
Xie Yutong(The Women and Children's Hospital of Qinghai,810007)
出处
《高原医学杂志》
CAS
2023年第2期7-11,共5页
Journal of High Altitude Medicine
关键词
N末端脑钠肽前体
高原性心脏病
心力衰竭
儿童
N-terminal pro brain natriuretic peptide
High altitude heart disease
Heart failure
Children
