摘要
●Retinoblastoma(RB)is the most common intraocular malignancy of childhood caused by inactivation of the Rb genes.The prognosis of RB is better with an earlier diagnosis.Many diagnostic approaches and appropriate clinical treatments have been developed to improve clinical outcomes.However,limitations exist when utilizing current methods.Recently,many studies have identified identify new RB biomarkers which can be used in diagnosis,as prognostic indicators and may contribute to understanding the pathogenesis of RB and help determine specific treatment strategies.This review focuses on recent advances in the discovery of RB biomarkers and discusses their clinical utility and challenges from areas such as epigenetics,proteomics and radiogenomics.
● Retinoblastoma(RB) is the most common intraocular malignancy of childhood caused by inactivation of the Rb genes. The prognosis of RB is better with an earlier diagnosis. Many diagnostic approaches and appropriate clinical treatments have been developed to improve clinical outcomes. However, limitations exist when utilizing current methods. Recently, many studies have identified identify new RB biomarkers which can be used in diagnosis, as prognostic indicators and may contribute to understanding the pathogenesis of RB and help determine specific treatment strategies. This review focuses on recent advances in the discovery of RB biomarkers and discusses their clinical utility and challenges from areas such as epigenetics, proteomics and radiogenomics.
基金
Supported by the National Natural Science Foundation of China(No.81672673)
the National Key Research and Development Program of China(No.2017YFA0104101).
作者简介
Co-first authors:Jie Sun;Co-first authors:Hui-Yu Xi;Correspondence to:Qing Shao,Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China.13913862499@139.com;Qing-Huai Liu.Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China.liuqh@njmu.edu.cn
