摘要
个性化精准医疗是现代临床医学的核心追求,3D打印技术以CT、MRI等影像数据为基础,以逐层叠加打印为手段,实现与患处的个性化匹配和精准治疗,开创了医工协作攻关的新纪元。本文从仿生打印模型、个性化金属植入物和生物打印3个方面阐述3D打印技术在骨关节外科领域的典型应用,阐明骨关节仿生模型在手术教学、实践和可视化医患沟通中的显著效果,但影像分辨率和打印精度尚待提高;分析金属植入物尤其是3D打印多孔钽在大段骨缺损治疗中的安全性和有效性,以及生物打印骨与软骨的诸多尝试和生物墨水与细胞存活等方面的挑战。3D打印技术促进了骨关节外科诊疗水平的提高,未来将持续研发仿生超精细模型,深入研究钽金属微观结构特性对生物学功能的影响,制备高品质钽植入物,同时探索骨组织工程打印技术的突破方向。
Personalized precision medicine is the core pursuit of modern clinical medicine.Based on CT,MRI,and other image data,3 D printing technology achieves personalized matching and precise treatment with the affected area through layer-by-layer superposition printing and promotes new cooperation between medicine and industry.This paper expounds on the typical application of 3 D printing technology in the field of bone and joint surgery from 3 aspects:bionic printing model,metallic implants,and bioprinting.The remarkable effects of a bone joint bionic model are further clarified in surgical teaching,practice,and visual doctor-patient communication,but the image resolution and printing accuracy need to be further improved.We analyze the safety and effectiveness of metal implants,especially 3 D printed porous tantalum,in the treatment of large bone defects,and many attempts of bioprinting bone and cartilage,as well as the challenges of biological ink and cell survival.3 D printing technology has promoted the improvement of the diagnosis and treatment of bone and joint surgery.In the future,researches should further study the effect of tantalum microstructure on biological function,prepare high-quality tantalum implants,and explore the breakthrough direction of bone tissue engineering printing technology.
作者
王富友
王浦全
WANG Fuyou;WANG Puquan(Center for Joint Surgery,First Affiliated Hospital,Army Medical University(Third Military Medical University),Chongqing,400038,China)
出处
《陆军军医大学学报》
CAS
CSCD
北大核心
2022年第15期1508-1515,共8页
Journal of Army Medical University
基金
国家自然科学基金面上项目(82172429)
作者简介
通信作者:王富友,博士,副主任医师,博士生导师。担任重庆市增材制造产业协会医学3D打印分会会长、中国医疗器械行业协会再生医学技术产业专业委员会常务委员、中国医师协会骨科医师分会骨科基础工作委员会委员。主持国家“十三五”重点研发专项分题1项,国家自然科学基金面上项目3项,获得中国博士后科学基金二等资助和特别资助各1项。获军队科技进步二等奖1项。发表学术论文62篇,其中SCI收录期刊论文28篇。获得美国专利1项,国家发明专利15项,实用新型专利22项。主要从事生物力学与组织工程、骨关节再生修复与生物3D打印等方面的研究。E-mail:wfy731023@163.com
