摘要
目的探讨儿童热性惊厥与频繁夜间遗尿症的关系,为遗尿症的危险因素提供研究依据,并分析在儿童不同年龄及性别中二者相关性的变化。方法用分层整群随机抽样的方法于2014年6月—2015年6月在上海市抽取3个市区和4个郊区,以5~12岁儿童为研究对象并分发问卷85860份,采用多因素Logistic回归分析热性惊厥与频繁夜间遗尿症的关系,敏感性分析观察二者相关性在年龄和性别中的变化。结果上海市共有62290名5~12岁儿童纳入研究。控制混杂因素后,多因素分析显示热性惊厥儿童患频繁夜间遗尿症的风险较高(OR=7.740,95%CI:5.512~10.870,P<0.001)。随着儿童年龄增加二者相关性越强(P<0.001),尤其在女童中(OR=13.798,95%CI:8.056~23.631,P<0.001)比男童(OR=4.422,95%CI:2.580~7.579,P<0.001)更为显著。结论热性惊厥与频繁夜间遗尿症显著相关,尤其在高年龄组与女童中更为显著,提示热性惊厥为频繁夜间遗尿症的危险因素之一。
Objective To investigate the associations between febrile seizures and frequent nocturnal enuresis, so as to provide evidence for study of risk factors for enuresis and explore the changes of the associations in different ages and genders. Methods A stratified cluster random sampling method was used to select 85 860 children aged 5 to 12 years in 3 urban areas and 4 suburbs in Shanghai from June 2014 to June 2015, and children were asked to fill out questionnaire. Multivariate Logistic regression analysis was used to analyze the association between febrile seizures and frequent nocturnal enuresis. Sensitivity analysis was performed to observe the changes of association in ages and genders. Results Finally 62 290 valid questionnaires were enrolled in this study. Multivariate analysis showed that children with febrile seizures still had a high risk of enuresis after controlling for confounding factors(OR=7.740, 95%CI:5.512-10.870, P<0.001). In addition, the association between the two increased with ages(P<0.001), which was more significant in girls(OR=13.798, 95%CI:8.056-23.631, P<0.001) than boys(OR=4.422, 95%CI:2.580-7.579, P<0.001). Conclusion Febrile seizures is significantly associated with frequent nocturnal enuresis, especially in older age groups and girls, suggesting that FS is one of the risk factors for frequent nocturnal enuresis.
作者
毛艺
沈佳瑶
钟少根
金星明
马骏
MAO Yi;SHEN Jia-yao;ZHONG Shao-gen;JIN Xing-ming;MA Jun(Department of Developmental and Behavioral Pediatrics,Shanghai Children′s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Nephrology,Shanghai Children′s Medical Center,School of Medicine,Shanghai Jiao Tong University)
出处
《中国儿童保健杂志》
CAS
CSCD
2023年第2期147-151,170,共6页
Chinese Journal of Child Health Care
基金
上海市2020年度“科技创新行动计划”自然科学基金项目(20ZR1434700)
上海市2022年度“科技创新行动计划”医学创新研究专项项目(22Y11920100)
上海市公共卫生体系建设三年行动计划(2011-2013)(11PH1951202)
关键词
频繁夜间遗尿症
热性惊厥
儿童
危险因素
性别
frequent nocturnal enuresis
febrile seizures
children
risk factors
gender
作者简介
毛艺(1999-),女,安徽人,在读硕士研究生,主要研究方向为发育行为儿科;通信作者:马骏,E-mail:majun@shsmu.edu.cn
