摘要
目的探讨无创呼吸机(non-invasive ventilator,NIV)联合纳洛酮(naloxone,NX)治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期合并Ⅱ型呼吸衰竭(typeⅡrespiratory failure,Ⅱ-RF)的临床效果。方法选择佛山市南海经济开发区人民医院2021年1—12月收治的COPD急性期合并Ⅱ-RF患者100例,随机分为对照组和观察组各50例。在常规治疗基础上,对照组加用NIV辅助通气;而观察组在对照组基础上加用NX。比较两组患者治疗前和治疗7 d后的血气分析指标、肺功能指标和炎症因子指标。结果治疗后,观察组酸碱度、氧分压水平高于对照组,而二氧化碳分压水平低于对照组,差异有统计学意义(P>0.05);观察组用力肺活量、第1秒用力呼气容积和呼气高峰流量水平均高于对照组,差异有统计学意义(P>0.05);观察组C反应蛋白、肿瘤坏死因子-α和白介素-8水平低于对照组,差异有统计学意义(P>0.05)。结论NIV联合NX治疗COPD急性加重期合并Ⅱ-RF,能够进一步改善患者的酸碱平衡和呼吸功能,并能够促进炎症反应进一步消退,值得推广应用。
Objective To investigate the clinical effect of noninvasive ventilator(NIV)combined with naloxone(NX)in the treatment of chronic obstructive pulmonary disease(COPD)with type II respiratory failure(II-RF)at the acute exacerbation stage.Methods A total of 100 patients with COPD complicated withⅡ-RF in acute stage admitted to People’s Hospital of Foshan Nanhai Economic Development Zone from January to December 2021 were randomly divided into control group and observation group with 50 patients in each group.On the basis of routine treatment,NIV was added to the control group.The observation group added NX on the basis of the control group.The blood gas analysis index,pulmonary function index and inflammatory factor index were compared between the two groups before and after 7-day treatment.Results After treatment,the pH and oxygen partial pressure levels in the observation group were significantly higher than those in the control group,while carbon dioxide partial pressure levels were significantly lower than those in the control group(P>0.05).The levels of forced vital capacity,forced expiratory volume in one second and peak expiratory flow rate in the observation group were significantly higher than those in the control group(P>0.05).C-reactive protein,tumor necrosis factor-αand interleukin-8 in observation group were significantly lower than those in the control group(P>0.05).Conclusion NIV combined with NX can further improve the acid-base balance and respiratory function of patients with acute exacerbation of COPD complicated withⅡ-RF,and can promote the further regression of inflammatory reaction,which is worth popularizing.
作者
巫建芳
张显风
李志铿
罗建军
梁贵枝
WU Jianfang;ZHANG Xianfeng;LI Zhikeng;LUO Jianjun;LIANG Guizhi(Department of Respiratory Medicine,People's Hospital of Nanhai Economic Development Zone,Foshan 528234,Guangdong Province,China)
出处
《中国实用乡村医生杂志》
2022年第12期69-72,共4页
Chinese Practical Journal of Rural Doctor
关键词
慢性阻塞性肺疾病
急性加重期
呼吸衰竭
Ⅱ型
纳洛酮
无创呼吸机
Chronic Obstructive Pulmonary Disease
Acute Exacerbation
Respiratory Failure
TypeⅡ
Naloxone
Non-invasive Ventilator
