摘要
目的探讨妥布霉素地塞米松与玻璃酸钠联合治疗干眼症(DES)的临床疗效。方法选取2021年1月—2023年6月于本院接受诊治的80例DES患者为研究对象,按随机数字表法将其分为对照组和观察组,各40例。其中对照组采用妥布霉素地塞米松治疗,观察组在此基础上采用玻璃酸钠治疗。比较两组的临床疗效、炎症因子水平、泪膜功能及不良反应发生情况。结果观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗前,两组炎症因子水平及泪膜功能比较,组间差异无统计学意义(P>0.05);治疗后,观察组白细胞介素-1β、超敏C反应蛋白、白细胞介素-6及肿瘤坏死因子-ɑ水平均低于对照组,泪膜破裂时间、基础泪液分泌试验均长于对照组,泪膜厚度厚于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论妥布霉素地塞米松与玻璃酸钠联合治疗DES可有效减轻患者眼部的炎症反应,促进患者泪膜功能恢复,且不会增加不良反应发生,值得推广。
Objective Exploring the clinical efficacy of tobramycin and dexamethasone combined with sodium hyaluronate in the treatment of dry eye syndrome(DES).Methods 80 DES patients who received treatment in our hospital from January 2021 to June 2023 were selected as the research subjects.They were divided into a control group and an observation group using a random number table method,with 40 patients in each group.The control group received treatment with tobramycin and dexamethasone,while the observation group received treatment with sodium hyaluronate on this basis.Compare the clinical efficacy,levels of inflammatory factors,tear film function,and incidence of adverse reactions between two groups.Results The total effective rate of the observation group was 95.00%,which was higher than the control group's 80.00%,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of inflammatory factors and tear film function between the two groups(P>0.05);after treatment,the levels of interleukin-1β,hypersensitive C-reactive protein,interleukin-6,and tumor necrosis factor-ɑin the observation group were lower than those in the control group,and the tear film rupture time and basic tear secretion test were longer than those in the control group,and the tear film thickness was thicker than that in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of tobramycin,dexamethasone,and sodium hyaluronate in the treatment of DES can effectively alleviate eye inflammation in patients,promote the recovery of tear film function,and it will not increase the occurrence of adverse reactions.It is worth promoting.
作者
尉明花
WEI Minghua(Department of Ophthalmology,Yutai County People's Hospital,Jining Shandong,272300,China)
出处
《反射疗法与康复医学》
2024年第7期96-98,117,共4页
Reflexology And Rehabilitation Medicine
关键词
干眼症
妥布霉素地塞米松
玻璃酸钠
炎症反应
泪膜功能
Dry eye syndrome
Tobramycin and dexamethasone
Sodium hyaluronate
Inflammatory response
Tear film function
作者简介
尉明花(1980-),女,山东济宁人,本科,主治医师,研究方向:眼科疾病诊治。
