摘要
目的探讨阿卡波糖联合预混胰岛素在2型糖尿病患者中的治疗效果。方法选取2022年12月—2023年9月牡丹江医学院附属红旗医院收治的92例2型糖尿病患者为研究对象,按随机数字表法将其分为对照组和观察组,各46例。对照组采用阿卡波糖治疗,观察组在对照组基础上加用预混胰岛素治疗。对比两组临床疗效、血糖指标、胰岛功能及不良反应发生率。结果观察组治疗总有效率95.65%高于对照组的80.43%,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖(6.87±1.21)mmol/L、餐后2 h血糖(8.05±1.86)mmol/L、糖化血红蛋白(6.04±0.67)%、胰岛素抵抗指数(1.12±0.23),均低于对照组的(7.95±1.02)mmol/L、(9.79±1.43)mmol/L、(7.31±0.92)%、(1.65±0.34),胰岛β细胞功能指数(45.20±5.94),高于对照组的(38.45±5.02),组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿卡波糖联合预混胰岛素治疗2型糖尿病,可提高临床疗效改善血糖指标,促进胰岛功能恢复正常,且安全性高。
Objective To investigate the therapeutic effect of acarbose combined with premixed insulin in patients with type 2 diabetes.Methods A total of 92 patients with type 2 diabetes admitted to the Hongqi Hospital affiliated to Mudanjiang Medical College from December 2022 to September 2023 were selected as the research objects and divided into a control group and an observation group according to the random number table,with 46 cases in each group.The control group was treated with acarbose,while the observation group was treated with premixed insulin.Compare the clinical efficacy,blood glucose indicators,islet function,and incidence of adverse reactions between two groups.Results The total effective rate of the observation group was 95.65%,which was higher than the control group's 80.43%,and the difference was statistically significant(P<0.05).After treatment,the fasting blood glucose(6.87±1.21)mmol/L,2-hour postprandial blood glucose(8.05±1.86)mmol/L,glycated hemoglobin(6.04±0.67)%,and insulin resistance index(1.12±0.23)in the observation group were all lower than(7.95±1.02)mmol/L,(9.79±1.43)mmol/L,(7.31±0.92)%,and(1.65±0.34)in the control group,and the pancreatic beta cell function index(45.20±5.94)was higher than(38.45±5.02)in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Acarbose combined with premixed insulin can treat type 2 diabetes and improve clinical efficacy,improve blood glucose indicators,and promote the recovery of islet function,with high safety.
作者
孙悦
陈传志
SUN Yue;CHEN Chuanzhi(Department of Endocrinology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157000,China;Party and Government Comprehensive Office,Hongqi Hospital affiliated to Mudanjiang Medical College,Mudanjiang 157000,China)
出处
《反射疗法与康复医学》
2024年第9期104-106,共3页
Reflexology And Rehabilitation Medicine
关键词
2型糖尿病
阿卡波糖
预混胰岛素
临床疗效
血糖指标
胰岛功能
Type 2 diabetes
Acarbose
Premixed insulin
Clinical efficacy
Blood glucose indicators
Islet function
作者简介
孙悦(1990-),女,黑龙江牡丹江人,本科,住院医师,研究方向:内分泌疾病诊治;通信作者:陈传志(1988-),男,黑龙江牡丹江人,本科,主治医师,研究方向:内分泌、甲状腺疾病诊治,邮箱:21956437@qq.com。
