摘要
目的:观察小五味子汤加减联合孟鲁司特治疗小儿感染后慢性咳嗽的临床疗效。方法:选取兴国县妇幼保健院收治的86例小儿感染后慢性咳嗽患儿,按照随机数字表法分为两组,各43例,对照组采用孟鲁司特治疗,研究组在对照组基础上联用小五味子汤加减,对比两组临床疗效。结果:研究组治疗总有效率和咳嗽生活质量(LCQ)评分高于对照组,且中医证候积分、咳嗽症状积分表(CSS)评分与白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-a(TNF-a)、白细胞计数(WBC)水平,以及不良反应发生率和复发率低于对照组,止咳时间、鼻塞缓解时间和咽痛咽痒消失时间短于对照组(P<0.05)。结论:小五味子汤加减联合孟鲁司特治疗小儿感染后慢性咳嗽效果较好,能够显著改善患儿临床症状和预后表现,减轻炎症刺激,治疗安全性和实用性较高。
ObjectiveObservation of the clinical efficacy of Xiaowuweizi decoction combined with montelukast in the treatment of chronic cough in children after infection.Methods Selecting 86 children with chronic cough after infection admitted to Xingguo County Maternal and Child Health Hospital,they were randomly divided into two groups using a random number table method,with 43 cases in each group.The control group was treated with montelukast,while the study group was treated with Xiaowuweizi decoction on the basis of the control group.The clinical efficacy of the two groups was compared.Results The total effective rate and cough quality of life(LCQ)score of the study group were higher than those of the control group,and the TCM syndrome score,cough symptom score(CSS)score,interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-a(TNF-a),white blood cell count(WBC)levels,incidence and recurrence of adverse reactions were lower than those of the control group.The cough relief time,nasal congestion relief time,and disappearance time of pharyngeal pain and itching in the study group were shorter than those of the control group(P<0.05).Conclusion The combination of modified Xiao Wu Wei Zi Tang and Montelukast has a good effect on treating chronic cough in children after infection.It can significantly improve the clinical symptoms and prognosis of children,reduce inflammatory stimulation,and has high safety and practicality in treatment.
出处
《黑龙江中医药》
2024年第1期37-39,共3页
Heilongjiang Journal of Traditional Chinese Medicine
基金
项目编号GZ2023ZSF670,赣州市指导性科技计划项目
关键词
小五味子汤加减
孟鲁司特
小儿感染后慢性咳嗽
炎症因子
临床疗效
Xiao Wu Wei Zi Tang with modifications
Monlust
Chronic cough in children after infection
Inflammatory factors
Clinical efficacy
