摘要
目的探讨电针对体外授精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)反复移植失败(recurrent implantation failure,RIF)患者的临床疗效及可能的作用机制。方法将104例RIF患者随机分为两组,对照组给予常规激素替代治疗,试验组加用电针治疗,对比两组患者的临床妊娠率评估疗效,对比两组患者治疗后子宫内膜厚度,焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)得分探索电针治疗RIF可能的作用机制。结果治疗后,试验组的临床妊娠率明显高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后子宫内膜厚度,SAS、SDS得分较治疗前均明显改善(P<0.01或0.05),且试验组治疗后子宫内膜厚度,SAS、SDS得分较对照组改善更明显,差异有统计学意义(P均<0.01)。结论电针治疗RIF患者的临床妊娠率,其作用机制可能与改善患者子宫内膜厚度,促进子宫内膜的生长,以及改善RIF患者的焦虑抑郁状态,调适心理有关。
Objective To investigate the clinical effect and mechanism of electroacupuncture therapy in patients with recurrent implantation failure(RIF)in vitro fertilization and embryo transfer(IVF-ET).Methods A total of 104 patients with RIF in IVF-ET were randomly divided into two groups,the control group was given routine hormone replacement treatment,the experimental group treated with electroacupuncture on the basic treatment of the control group.The efficacy was assessed by comparing the clinical pregnancy rate,endometrial thickness,anxiety self-rating scale(SAS)score,and depression self-rating scale(SDS)score after treatment in the two groups.Results After treatment,the clinical pregnancy rate of the experimental group was significantly higher than that of the control group(P<0.05).The endometrial thickness,SAS and SDS scores of the two groups after treatment were significantly improved compared with those before treatment(P<0.01 or 0.05),and the endometrial thickness,SAS and SDS scores of the experimental group were improved more significantly than those of the control group after treatment(all P<0.01).Conclusion The mechanism of electroacupuncture for the clinical pregnancy rate of patients with RIF may be related to the improvement of endometrial thickness,promotion of endometrial growth,improvement of anxiety and depression in RIF patients,and psychological adjustment.
作者
邓超
陈利锋
马冉
王月燊
陈芸芸
郑清
孔立红
DENG Chao;CHEN Lifeng;MA Ran;WANG Yueshen;CHEN Yunyun;ZHENG Qing;KONG Lihong(College of Acupuncture and Orthopedics,Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430065,China)
出处
《华南国防医学杂志》
CAS
2020年第6期393-396,共4页
Military Medical Journal of South China
基金
国家中医药管理局中医药传承与创新‘百千万’人才工程(岐黄工程)(HBPCIC-2019-06)
关键词
电针
反复移植失败
子宫内膜厚度
焦虑
抑郁
Electroacupuncture
Recurrent implantation failure
Endometrial thickness
Anxiety
Depression
作者简介
通信作者:孔立红,E-mail:xiyu1618@sina.com
