摘要
目的研究超声波、sPL(超活化血小板裂解液)注射联合治疗促进兔跟腱断裂术后康复的效果。方法选取24只3~4月龄新西兰白兔制造跟腱断裂术后模型,随机将其分为4组:A、B、C、D,每组6只。A组为对照组,每周注射一次生理盐水0.2 mL;B组采用超声波治疗,同时每周注射生理盐水0.2 mL;C组每周注射sPL 0.2 mL;D组采用sPL和超声波联合治疗,超声波治疗的同时每周注射一次sPL 0.2 mL。3个月后测定跟腱的最大断裂负荷、I型胶原蛋白和III型胶原蛋白含量。结果D组与其他三组相比,修复的跟腱可承受的断裂负荷最大、拥有I型胶原蛋白含量最高、III型胶原蛋白含量最低(均P<0.05)。结论sPL与超声波联合治疗能更好地促进兔跟腱断裂术后的康复,为sPL与超声波联合治疗的临床应用提供实验依据。
Objective To study the effect of combined SPL and ultrasound on rehabilitation of rabbits with achilles tendon rupture after operation.Methods Twenty-four New Zealand white rabbits aged 3 to 4 months were selected to make postoperative Achilles tendon rupture models,and they were randomly divided into 4 groups:A,B,C,D,6 in each group.Group A was the control group and injected 0.2 mL of normal saline once a week;group B was treated with ultrasound and 0.2 mL of saline was injected weekly;group C was injected with 0.2 mL of sPL weekly;group D was treated with combined sPL and ultrasound.To:Inject ultrasound with 0.2 mL sPL once a week during ultrasound treatment.Determine the maximum rupture load,typeⅠcollagen and typeⅢcollagen content of the Achilles tendon after 3 months.Results Compared with the other three groups,the repaired Achilles tendon withstanded the largest rupture load(P<0.05),the highest content of type I collagen,and the lowest content of type III collagen(P<0.05).Conclusion The combined treatment of sPL and ultrasound can better promote the rabbit Achilles tendon rehabilitation after rupture,provide experimental basis for clinical application of sPL combined with ultrasound.
作者
孙嘉泽
王文波
SUN Jia-ze;WANG Wen-bo(Department of Orthopedic Surgery,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《哈尔滨医科大学学报》
CAS
2020年第5期482-484,共3页
Journal of Harbin Medical University
关键词
SPL
超声波治疗
跟腱断裂
康复治疗
SPL
ultrasound treatment
Achilles tendon rupture
rehabilitation treatment
作者简介
孙嘉泽(1992-),男,住院医师,硕士;通讯作者:王文波,Email:wangwenbo@hrbmu.edu.cn
