摘要
目的评估结直肠癌发生风险与遗传风险评分及生活方式风险评分之间的关系。方法选取2015年至2020年诊治的结直肠癌患者316例作为观察组,选取同时期323例健康者作为对照组,使用13个单核苷酸多态性(SNP)量化结直肠癌的遗传风险评分,通过肥胖、体育活动、吸烟、饮酒和饮食炎症指数(DII)5个危险因素确定生活方式风险评分。使用Logistic回归模型分析遗传风险评分、生活方式风险评分与结直肠癌发生风险的关系。结果遗传风险评分越高,患结直肠癌的风险越高[OR(95%CI):2.87(2.05~4.01)2.57(1.89~3.49)]。生活方式危险因素中,肥胖、缺乏身体活动、大量饮酒和高炎症饮食与结直肠癌风险增加有关。生活方式风险评分越高,患结直肠癌的风险越高[OR(95%CI):2.82(2.02~5.44)5.82(4.02~8.44)]。随着遗传风险评分和生活方式风险评分的增加,结直肠癌风险也随之增加,且生活方式风险评分造成的结直肠癌风险增加得更多。两种评分均最高的参与者患结直肠癌的风险是均最低的参与者的12倍[OR(95%CI):5.57(1.77~17.39)12.57(5.77~27.39)],且直肠癌患者强于结肠癌患者。结论无论个人的遗传风险如何,坚持健康的生活方式可以显著降低结直肠癌的发生风险。
Objective To evaluate the relationship between the risk of colorectal cancer and genetic risk score and lifestyle risk score.Methods Totally 316 patients with colorectal cancer diagnosed and treated from 2015 to 2020 were selected as the observation group,and 323 healthy patients at the same period were selected as the control group.13 single nucleotide polymorphisms(SNPs)were used to quantify the genetic risk of colorectal cancer.Determined the lifestyle risk score based on five risk factors:obesity,physical activity,smoking,drinking,and dietary inflammation index(DII).Logistic regression model was used to analyze the relationship between genetic risk score,lifestyle risk score and the risk of colorectal cancer.Results The higher the genetic risk score,the higher the risk of colorectal cancer[OR(95%CI):2.87(2.05~4.01)2.57(1.89~3.49)].Among the lifestyle risk factors,obesity,lack of physical activity,heavy drinking,and high-inflammatory diet were associated with an increased risk of colorectal cancer.The higher the lifestyle risk score,the higher the risk of colorectal cancer[OR(95%CI):2.82(2.02~5.44)5.82(4.02~8.44)].As the genetic risk score and lifestyle risk score increase,the risk of colorectal cancer also increases,and the risk of colorectal cancer caused by the lifestyle risk score increases even more.The risk of colorectal cancer in the participants with the highest two scores was 12 times that of the participants with the lowest[OR(95%CI):5.57(1.77~17.39)12.57(5.77~27.39)],and patients with rectal canceris stronger than colon cancer patients.Conclusion Regardless of the individual’s genetic risk,adhering to a healthy lifestyle can significantly reduce the risk of colorectal cancer.
作者
汤德珍
孟杨
朱礼明
陈勇
顾凯
兰平
TANG De-zhen;MENG Yang;ZHU Li-ming;CHEN Yong;GU Kai;LAN Ping(Shanghai Baoshan Center for Disease Control and Prevention,Shanghai 201900,China)
出处
《医药论坛杂志》
2021年第19期97-101,共5页
Journal of Medical Forum
基金
国家重点研发计划(2017YFC1308803)
