摘要
高精氨酸(Homoarginine,hArg)是一种内源性非蛋白氨基酸,与精氨酸(Arginine,Arg)为一对同源氨基酸,是一氧化氮(nitric oxide,NO)合成的底物。近期研究表明,hArg在心血管、肝脏、神经功能以及宫内生长受限中发挥重要作用。与Arg相比,hArg在人类和动物研究中的应用还处于初级阶段,其作用机制尚未完全证实。该文综述了hArg的合成、转运及代谢途径,旨在为功能性氨基酸在动物生产中的应用提供理论支持。
Homoarginine(hArg)is an endogenous non-protein amino acid,a pair of homologous amino acids to Arg,and is the synthetic substrate of NO synthesis.Recent studies have shown that hArg plays an important role in cardiovascular,liver,neurological function,and intrauterine growth restriction.However,compared with Arg,the application of hArg in human and animal research is still at an early stage,and its mechanism of action has not been fully proved.Therefore,the synthesis,transport and metabolic pathways of hArg were reviewed to provide theoretical support for the application of functional amino acids in animal production.
作者
车东升
李慧鹃
赵宝
CHE Dongsheng;LI Huijuan;ZHAO Bao(College of Animal Science and Technology,Jilin Agricultural University,Key Laboratory of Animal Production and Product Quality and Security,Ministry of Education,Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science,Changchun 130118,China)
出处
《吉林农业大学学报》
CAS
CSCD
北大核心
2020年第5期477-485,共9页
Journal of Jilin Agricultural University
基金
国家自然科学基金面上项目(32072747)
关键词
高精氨酸
精氨酸
代谢机制
homoarginine
arginine
metabolic mechanism
作者简介
第一作者:车东升,男,博士,教授,研究方向:动物营养代谢;第一作者:李慧鹃,女,在读硕士,研究方向:动物营养代谢;通信作者:车东升
