摘要
The lung plays a vital role in maintaining homeostasis,as it is responsible for the exchange of oxygen and carbon dioxide.Pulmonary homeostasis is maintained by a network of tissue-resident cells,including epithelial cells,endothelial cells and leukocytes.Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung.Recently developed unbiased next generation sequencing(NGS)has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge.New phenotypes and distinct gene signatures have been identified,and these new findings enhance the diagnosis and treatment of lung diseases.Here,we present a review of the new NGS findings on myeloid cells in lung development,homeostasis,and lung diseases,including acute lung injury(ALI),lung fibrosis,chronic obstructive pulmonary disease(COPD),and lung cancer.
The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing(NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury(ALI), lung fibrosis, chronic obstructive pulmonary disease(COPD), and lung cancer.
基金
the USA National Institutes of Health Grant R01-HL-079669(J.F.)
USA National Institutes of Health Grant R01HL076179(J.F.)
USA National Institutes of Health Grant R01HL-139547(J.F.)
VA Merit Award 1I01BX002729(J.F.)
VA BLR&D Award 1IK6BX004211(J.F.).
作者简介
Corresponding author:Jie Fan,if7@pitt.edu
