摘要
目的探讨内镜下黏膜切除术对老年患者胃肠道息肉切除后红细胞免疫功能、炎性因子的影响。方法选取北部战区总医院自2017年4月至2018年10月收治的72例老年胃肠道息肉患者为研究对象。根据不同的治疗方法将其分为A组与B组,每组各36例。给予A组患者常规内镜下电凝切除术治疗,给予患者B组内镜下黏膜切除术治疗。记录并比较两组老年患者胃肠道息肉切除后红细胞免疫功能及炎性因子水平。结果治疗后,B组患者白细胞分化抗原58(CD58)、白细胞分化抗原59(CD59)、淋巴细胞功能相关抗原3(LFA-3)、红细胞免疫复合物受体花环率(ICRRR)及红细胞C3b受体花环率(C3bRR)水平均高于A组,差异均有统计学意义(P<0.05);治疗后,B组患者白细胞介素(IL)-1β、IL-6、IL-8及IL-12水平均低于A组,差异均有统计学意义(P<0.05);A组患者并发症发生率为22.2%(8/36),高于B组的5.6%(2/36),差异有统计学意义(P<0.05)。结论内镜下黏膜切除术治疗老年胃肠道息肉患者临床效果显著,可增强老年患者的红细胞免疫功能,同时降低其炎性因子水平,且并发症发生率较低。
Objective To investigate the effect of endoscopic mucosal resection on the immune function of red blood cells and inflammatory factors after excision of gastrointestinal polyps in elderly patients.Methods A retrospective study was performed on 72 cases of elderly patients with gastrointestinal polyps who were admitted from April 2017 to October 2018.According to different treatment methods,patients were divided into Group A and Group B,with 36 cases in each group.Patients in Group A were treated with conventional endoscopic electrocoagulation resection,while patients in Group B were treated with endoscopic mucosal resection.The levels of erythrocyte immune function and inflammatory factors after gastrointestinal polypectomy were recorded and compared between the two groups.Results After treatment,the levels of cluster of diffferentiation 58(CD58),cluster of diffferentiation 59(CD59),lymphocyte function associated antigen-3(LFA-3),immune complex receptor rosette(ICRRR)and red blood cell C3 b receptor rosette(C3 bRR)in Group B were all higher than those in Group A,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin(IL)-1β,IL-6,IL-8 and IL-12 in Group B were all lower than those in Group A(P<0.05).The incidence of complications in Group A was 22.2%(8/36),higher than that in Group B(5.6%,2/36),P<0.05.Conclusion Endoscopic mucosal resection has a significant clinical effect in the treatment of elderly patients with gastrointestinal polyps,which can enhance the immune function of red blood cells in elderly patients,and reduce the level of inflammatory factors,with low incidence of complications.
作者
李成坤
孟凡军
LI Cheng-kun;MENG Fan-jun(Department of Gastroenterology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2020年第9期1024-1026,共3页
Clinical Journal of Medical Officers
关键词
内镜下黏膜切除术
胃肠道息肉
红细胞免疫功能
炎性因子
Endoscopic mucosal resection
Gastrointestinal polyps
Red blood cell immune function
Inflammatory factor
作者简介
第一作者:李成坤(1983-),女,辽宁沈阳人,主治医师;通信作者:孟凡军,E-mail:mfj93@163.com
