摘要
目的探讨应用双抗联合阿加曲班治疗急性缺血性卒中后影响活化部分凝血活酶时间(APTT)早期达标的因素。方法选取自2017年1月至2019年6月北部战区总医院神经内科收治的应用阿加曲班治疗的62例急性缺血性卒中患者为研究对象。根据APTT达标情况将患者分为早期达标组(n=26)与早期不达标组(n=36)。收集患者入院时的年龄、性别、体温、收缩压、舒张压、合并用药、吸烟史、饮酒史、肝肾功能、合并用药、合并疾病情况等信息,应用二元逻辑回归分析影响APTT早期达标的因素。结果APTT早期达标组与早期不达标组的年龄及合并应用硫酸氢氯吡格雷的患者比例比较,差异有统计学意义(P<0.05)。两组患者的性别、体温、收缩压、舒张压、吸烟史、饮酒史、肝肾功能、合并疾病情况比较,差异均无统计学意义(P>0.05)。二元逻辑回归分析结果显示,只有年龄与APTT早期达标相关(P<0.05),而合并应用硫酸氢氯吡格雷、性别、谷丙转氨酶水平、谷草转氨酶水平与APTT早期达标均无关(P>0.05)。结论阿加曲班用于治疗急性缺血性卒中时,给药后2 h的APTT是否达标可能与年龄相关。
Objective To investigate the factors influencing the early achievement of activated partial thrombin time(APTT)in the treatment of acute ischemic stroke with double antibody combined with agattroban.Methods A total of 62 patients with acute ischemic stroke treated with agattroban from January 2017 to June 2019 in the department of neurology,General Hospital of Northern Theater Command were selected as the study subjects.According to APTT compliance,patients were divided into early compliance group(n=26)and early non-compliance group(n=36).The age,gender,body temperature,systolic blood pressure,diastolic blood pressure,combined drug use,smoking history,drinking history,liver and kidney function,combined drug use,and disease conditions of patients at admission were collected.And the factors influencing the early APTT standard were analyzed by binary logistic regression.Results There were statistically significant differences in age and proportion of patients with combined application of clopidogrel hydrogen sulfate between the early compliance group and early non-compliance group(P<0.05).There were no statistically significant differences in gender,body temperature,systolic blood pressure,diastolic blood pressure,smoking history,drinking history,liver and kidney function,and complications between two groups(P>0.05).Binary logistic regression analysis showed that only age was correlated with early APTT achievement(P<0.05),while combined application of clopidogrel bisulfate,gender,alanine aminotransferase level and aspartate aminotransferase level were not correlated with early APTT achievement(P>0.05).Conclusion In the treatment of acute ischemic stroke,the attainment of APTT at 2 hours after agattroban administration may be correlated with age.
作者
唐小童
孙显辉
赵子艾
TANG Xiao-tong;SUN Xian-hui;ZHAO Zi-ai(Department of Clinical Laboratory,General Hospital of Northern Theater Command,Shenyang 110016,China;Department of Neurology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2022年第1期17-19,22,共4页
Clinical Journal of Medical Officers
基金
辽宁省博士启动基金(20180540145)
作者简介
第一作者:唐小童(1988-),女,重庆人,主管技师,硕士;通信作者:赵子艾,E-mail:zhaoziai@hotmail.com
