摘要
肝硬化是肝良性疾病发展至终末期肝病的中间阶段,从肝病变发展至肝硬化乃至终末期肝病的时间为5~20年。对于终末期肝病而言,肝移植手术作为唯一有效的治疗手段已得到认可。但是对于肝硬化患者而言,应何时采用肝移植治疗,目前尚未达成共识。肝硬化患者一方面病情处于动态变化过程中,肝功能在逐渐恶化;另一方面也会面临各种肝硬化门脉高压并发症,其严重程度也各不相同。本文结合目前关于肝硬化的相关国内外研究及指南,从不同角度对肝移植手术时机的选择进行综述。
Cirrhosis is the intermediate stage from benign liver disease to end-stage liver disease.The time from liver disease to cirrhosis and even end-stage liver disease may vary from 5 to 20 years.For end-stage liver disease,liver transplantation,as the only effective treatment,has been recognized.However,there is no consensus on when liver transplantation should be adopted in patients with cirrhosis.The liver function of patients with cirrhosis is deteriorating gradually,and the patients also face various portal hypertension complications.This article reviews the timing of liver transplantation for cirrhosis from different perspectives based on current researches and guidelines.
作者
吕少诚
郎韧
贺强
LYU Shaocheng;LANG Ren;HE Qiang(Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital,Beijing 100020,China)
出处
《解放军医学院学报》
CAS
2020年第8期821-825,共5页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金面上项目(81571825)
北京市自然科学基金青年项目(7194274)
关键词
肝硬化
肝移植
手术时机
治疗
临床实践指南
cirrhosis
liver transplantation
operation opportunity
treatment
clinical practice guidelines
作者简介
吕少诚,男,博士,主治医师。研究方向:肝移植及相关基础研究。Email:shaocheng0502@163.com;通信作者:贺强,男,博士生导师,科主任。Email:heqiang349@163.com
