摘要
巨噬细胞在动脉粥样硬化斑块的起始、进展阶段直至斑块破裂中起核心作用,改变代谢途径是决定巨噬细胞功能和疾病进展的关键因素。本文阐述了动脉粥样硬化斑块微环境的核心因素如何影响巨噬细胞代谢变化以及代谢变化如何反过来改变巨噬细胞的免疫效应和组织修复功能,并探讨利用免疫代谢调节疾病中巨噬细胞反应的挑战和机遇。
Macrophages play central roles in the initiation,growth,and ultimately rupture of atherosclerotic plaques.Altered metabolism is the key feature that dictates macrophage function and subsequent disease progression.This review explores how the core factors of plaque microenvironment shape the metabolic rewiring of macrophages in atherosclerosis as well as how these metabolic shifts in turn alter the immune-effector and tissue-reparative functions of macrophage.Finally,this review offers insight into the challenges and opportunities of using immune metabolism to modulate macrophage responses in disease.
作者
陈羽斐
沈伟
施海明
CHEN Yufei;SHEN Wei;SHI Haiming(Department of Cardiology,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《中国动脉硬化杂志》
CAS
2020年第1期74-80,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金面上项目(81673701,81573710).
作者简介
陈羽斐,硕士研究生,研究方向为冠心病与炎症反应,E-mail:13818401823@163.com;通信作者:沈伟,博士,副主任医师,研究方向为冠心病与血管新生,E-mail:drshenwei@aliyun.com。
