摘要
目的:分析2022年初144例苏州本土新型冠状病毒奥密克戎变异株(简称为Omicron)感染患者的不同年龄层临床特征,为Omicron感染患者的临床救治提供参考。方法:选取2022年2月14日—2022年3月6日苏州大学附属传染病医院收治的144例苏州本土Omicron感染患者作为研究对象,根据年龄不同分为未成年组(<18岁,22例)、中青年组(18~<60岁,95例)和老年组(≥60岁,27例),统计和分析不同年龄层患者在临床症状、实验室指标、症状持续时间、核酸转阴、治疗结局等方面的特点。结果:144例Omicron感染患者中,临床分型为轻型和普通型的分别有84例(占58.33%)和32例(占22.22%),接种过疫苗的有116例(占80.56%),其中接种1针、2针、3针的分别有10例、67例和39例;3组患者在发热、咳嗽、恶心呕吐、胸闷方面存在组间差异(P<0.05),其中未成年组患者在发热、咳嗽、胸闷方面的发生率高于其他2组(P<0.05);3组患者在淋巴细胞计数、谷草转氨酶、白蛋白、总蛋白、肌酐、D-二聚体、肌红蛋白等实验室指标方面存在组间差异(P<0.05);对于116例轻型和普通型Omicron感染患者,不同年龄层患者在咽部不适、鼻塞、恶心呕吐、食欲不振、腹泻等症状的持续时间方面存在组间差异(P<0.05),其中老年组患者的症状持续时间更长(P<0.05);3组患者在病程、住院时间、核酸转阴天数方面存在组间差异(P<0.05),其中老年组患者的病程、住院时间、核酸转阴天数均大于其他2组(P<0.05)。结论:此轮苏州本土Omicron感染疫情的患者以中青年为主,症状整体以轻型和普通型为主,但老年患者的病程、住院时间、核酸转阴天数相对更长,故临床在救治过程中应加强对老年患者的关注。
Objective:To analyze the clinical characteristics of 144 patients infected with SARS-Cov-2 Omicron variant(Omicron for short)at different ages in Suzhou at the beginning of 2022,and provide reference for clinical treatment of Omicron infected patients.Methods:A total of 144 patients with Omicron infection in Suzhou admitted to the Infectious Diseases Hospital affiliated to Soochow University from February 14,2022 to March 6,2022 were selected as the study subjects.According to their age,the patients were divided into the juvenile group(less than 18 years old,22cases),the young and middle-aged group(18 to less than 60 years old,95 cases)and the elderly group(greater than or equal to 60 years old,27 cases).The clinical symptoms,laboratory indexes,symptoms duration,nucleic acid conversion to negative.treatment outcome and other characteristics of the patients at different ages were statistically analyzed.Results:Of the 144 patients with Omicron infection,84(accounting for 58.33%)and 32(accounting for 22.22%)were clinically classified as mild and common types,and 116(accounting for 80.56%)were vaccinated.Among them,10,67and 39 cases were vaccinated with 1,2 and 3 vaccines,respectively.There were differences among the three groups in fever,cough,nausea and vomiting,and chest tightness(P<0.05).The incidence rate of fever,cough and chest tightness in the juvenile group was higher than that in the other two groups(P<0.05).There were differences among the three groups in laboratory indexes such as lymphocyte count,glutamic-oxaloacetic transaminase,albumin,total protein,creatinine,D-dimer and myoglobin(P<0.05).With regards to 116 patients with mild and common type Omicron infection,there were differences among the patients at different ages in the duration of symptoms such as pharyngeal discomfort,nasal congestion,nausea and vomiting,anorexia and diarrhea(P<0.05),and the duration of symptoms in the elderly group was longer(P<0.05).There were differences among the three groups in the course of disease,length of stay and days of nucleic acid conversion to negative(P<0.05),and the course of disease,length of stay and days of nucleic acid conversion to negative in the elderly group were greater than those in the other two groups(P<0.05).Conclusion:This round of local Omicron infection in Suzhou is mainly in young and middle-aged patients,mainly with mild and common symptoms,but the course of disease,length of stay and days of nucleic acid conversion to negative in the elderly patients are relatively longer.Therefore,more attention should be paid to the elderly patients in the treatment process.
作者
时翠林
程军平
张建平
孙钢
刘义安
吴妹英
陆静
曾令武
李小红
冉大伟
郝冬林
高静东
曹旭
薛文静
翟云良
SHI Cui-lin;CHENG Jun-ping;ZHANG Jian-ping;SUN Gang;LIU Yi-an;WU Mei-ying;LU Jing;ZENG Ling-wu;LI Xiao-hong;RAN Da-wei;HAO Dong-lin;GAO Jing-dong;CAO Xu;XUE Wen-jing;ZHAI Yun-liang(The Affiliated Infectious Diseases Hospital of Soochow University,Suzhou Jiangsu 215131,China;Suzhou Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine,Suzhou Jiangsu 215009,China;The Second People's Hospital affiliated to Soochow University,Suzhou Jiangsu 215008,China;Lei Yun Shang Pharmaceutical Co.,Ltd.,Suzhou Jiangsu 215009,China)
出处
《抗感染药学》
2022年第11期1581-1586,共6页
Anti-infection Pharmacy
基金
江苏省中医药管理局新型冠状病毒肺炎中医药防治应急研究专项(JSZYJ 202201)
苏州市科技局-民生科技项目(SS202011)
作者简介
时翠林(1982—),女,主治医师;通信作者:程军平(1981—),男,副主任药师,【电子邮箱】19828955@qq.com
