摘要
目的比较磁共振3D-UTE-Cones序列T2*WI及磁化传递率(MTR)对健康志愿者和银屑病关节炎患者跟腱及跟腱附着点成像结果的差异,提高该病的早期诊断水平。方法对14名健康志愿者的20个跟腱和跟腱附着点以及13例银屑病关节炎患者的21个跟腱和跟腱附着点进行扫描,对T2*和磁化传递(MT)进行测量并计算MTR。对不同回波时间扫描得到的T2*和MTR进行分析。结果3D-UTE-Cones序列提供了跟腱和跟腱附着点的高分辨率成像。银屑病关节炎患者的Cones-T2*和Cones-MTR值较健康志愿者增高。结论3D-UTE-Cones序列可用于银屑病关节炎患者的跟腱及跟腱附着点的形态学评价,T2*及MTR可作为银屑病关节炎患者治疗和诊断的评价指标。
Objective Investigate three-dimensional ultrashort echo time Cones(3 D-UTE-Cones)MR imaging as well as quantification of T2*and(MTR)of Achilles tendon and its enthesis of healthy volunteers and patients with psoriatic arthritis(PsA)using a 3 T scanner.Aim to improve the early diagnosis abilities of PsA.Methods Quantitative T2*,T2 and magnetization transfer ratio(MTR)measurements of Achilles tendon and its enthesis were performed on healthy volunteers(n=14)and PsA patients(n=13)with 3 D-UTE-Cones and clinical sequences at 3 T.T2*was measured via single-component fitting of UTE images from two interleaved dual echo 3 D-UTE-Cones acquisitions.MTR was measured with a dual echo 3 D-UTE-Cones MT sequence.Clinical morphological imaging and quantification of T2 with Carr-Purcell Meiboom-Gill(CPMG)sequence and MTR with a gradient recalled echo(GRE)sequence were also performed on each subject.T2*and MTR were analyzed for the two groups and the significance was evaluated.Results The 3 D-UTECones sequence provided high resolution imaging of entheses and tendons.Cones-T2*and Cones-MTR values were significantly higher for the PsA patients.GRE-MTR values showed no significant differences between the groups.No reliable T2 measurement could be achieved with the CPMG sequence due to insufficient signal from entheses and tendons.Conclusion The 3 D-UTE-Cones sequences can be used for morphological evaluation of entheses and tendons in PsA patients.T2*and the MTR can be use as evaluated biomarkers in PsA diagnosis and treatment.
作者
罗锦沛
吴会霞
周智凤
邱麟
周毅
李恒国
刘斯润
陈碧敏
LUO Jinpei;WU Huixia;ZHOU Zhifeng(Department of Radiology,Huzhou Municipal Central Hospital,Huzhou,Guangdong Provnice 516001,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第3期555-559,共5页
Journal of Clinical Radiology
作者简介
通讯作者:陈碧敏
