摘要
目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)、CD147水平与2型糖尿病(T2DM)患者颈动脉粥样硬化(CAS)的关系。方法选取我院收治的143例T2DM患者为T2DM组,根据颈动脉内膜中层厚度(CIMT)将T2DM患者分为CAS组(42例)和无CAS组(101例)。另选取同期于我院体检的60例健康者为对照组,比较T2DM组与对照组血清Lp-PLA2、CD147水平。比较CAS组与无CAS组患者一般资料、临床资料、实验室检查结果。采用多因素logistic回归分析探讨T2DM患者发生CAS的影响因素。采用受试者工作特征(ROC)曲线分析血清Lp-PLA2、CD147水平对T2DM患者发生CAS的预测价值。结果T2DM组患者血清Lp-PLA2、CD147水平明显高于对照组(P<0.05)。CAS组患者年龄、糖尿病病程、血清空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、Lp-PLA2、CD147水平均高于无CAS组,而高密度脂蛋白胆固醇(HDL-C)水平低于无CAS组(P<0.05)。多因素logistic回归分析结果显示,糖尿病病程≥10年、Hb A1c、LDL-C、Lp-PLA2、CD147为T2DM患者发生CAS的独立危险因素(P<0.05)。ROC曲线显示,Lp-PLA2联合CD147预测T2DM患者发生CAS的ROC曲线下面积(AUC)明显大于Lp-PLA2、CD147单一预测(P<0.05)。结论T2DM患者血清Lp-PLA2、CD147水平均明显升高,二者均为CAS发生的独立影响因素,联合检测血清Lp-PLA2和CD147水平可提升对T2DM患者发生CAS的预测价值。
Objective To investigate the relationship of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and CD147 levels with carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 143 cases T2DM patients admitted to our hospital were selected as the T2DM group,and they were divided into CAS group(42 cases)and non-CAS group(101 cases)according to carotid intima-media thickness(CIMT).And 60 healthy people with physical examination during the same period were selected as the control group.The serum Lp-PLA2 and CD147 levels were compared between T2DM group and control group.The general data,clinical data and laboratory results were compared between CAS group and non-CAS group.Multivariate logistic regression was used to analyze the influencing factors of CAS in T2DM patients,the receiver operating characteristic(ROC)curve analysis was used to analyze the predictive value of serum Lp-PLA2 and CD147 levels in T2DM patients.Results Serum Lp-PLA2 and CD147 levels in the T2DM group were significantly higher than those in the control group(P<0.05).The age,duration of diabetes,serum fasting plasma glucose(FPG),hemoglobin A1 c(Hb A1 c),low density lipoprotein cholesterin(LDL-C),hypersensitive C-reactive protein(hs-CRP),Lp-PLA2 and CD147 levels in group CAS were higher than those in non-CAS group,while high density lipoprotein cholesterin(HDL-C)level was lower than that in non-CAS group(P<0.05).Multivariate logistic regression analysis showed that diabetes mellitus course≥10 years,Hb A1 c,LDL-C,Lp-PLA2,CD147 were the independent risk factors for the occurrence of CAS in T2DM patients(P<0.05).The ROC curve shows that area under ROC curve(AUC)of predicted by Lp-PLA2 combined with CD147 in T2DM patients was significantly higher than that predicted by Lp-PLA2 and CD147 alone(P<0.05).Conclusion The level of serum Lp-PLA2 and CD147 in T2DM patients is significantly increased,they are independent factors in the occurrence of CAS.Combined detection of serum Lp-PLA2 and CD147 levels can improve the predictive value of the occurrence of CAS in T2DM patients.
作者
黄婷
王义刚
张燕燕
周青
徐书涛
Huang Ting;Wang Yigang;Zhang Yanyan;Zhou Qing;Xu Shutao(Department of Endocrine,Panzhihua Central Hospital,Panzhihua 617067,China;不详)
出处
《临床内科杂志》
CAS
2022年第1期30-33,共4页
Journal of Clinical Internal Medicine
基金
四川省卫生和计划生育委员会科研课题(18PJ0115)
攀枝花市中心医院院内科研立项项目(201737)
作者简介
通讯作者:徐书涛,E-mail:xicchuan7421@163.com
