摘要
目的探讨吲哚布芬对维持性血液透析(MHD)患者自体动静脉内瘘(AVF)血栓形成的疗效及安全性分析。方法回顾性纳入科新建或重建AVF的MHD患者73例,根据用药情况将其分为阿司匹林组(39例)和吲哚布芬组(34例)。在常规MHD治疗基础上,阿司匹林组给予阿司匹林肠溶片100 mg每日1次口服,吲哚布芬组给予吲哚布芬片100 mg每日1次口服。收集两组患者的一般临床资料、实验室检查结果、AVF生存时间及不良反应情况并比较。采用log-rank检验对两组患者的远期生存率进行统计分析。结果两组患者性别、年龄、吸烟史、建立AVF前透析龄、原发疾病、Hb、血肌酐(SCr)、尿素氮(BUN)、白蛋白(Alb)、尿酸、PLT计数、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、D-二聚体比较差异均无统计学意义(P>0.05)。吲哚布芬组患者AVF中位生存时间高于阿司匹林组,log-rank检验结果显示,吲哚布芬组AVF远期生存率高于阿司匹林组(P=0.018)。吲哚布芬组患者AVF功能障碍出现例次低于阿司匹林组(P=0.043)。吲哚布芬组患者由血栓形成导致AVF功能障碍例次低于阿司匹林组(P=0.028)。两组患者出现不良反应例次比较差异无统计学意义(P=0.300)。结论吲哚布芬可有效预防MHD患者AVF血栓形成,延长AVF寿命,且不良反应与阿司匹林比较无差别,安全性较好。
Objective To investigate the efficacy and safety of indolibufen in the treatment of autologous arteriovenous fistula(AVF)thrombosis in patients with maintenance hemodialysis(MHD).Methods Seventy-three MHD patients with newly constructed or reconstructed AVF were retrospectively enrolled.According to medication status,73 patients were divided into aspirin group(39 cases)and indobufen group(34 cases).On the basis of conventional MHD treatment,aspirin group was given aspirin enteric-coated tablet 100 mg orally once a day,and indocybufen group was given indocybufen tablet 100 mg orally once a day.General clinical data,laboratory examination results,AVF survival time and adverse reactions of the two groups were collected and compared.Log-rank test was used to analyze the long-term survival rate of patients in the two groups.Results There were no statistically significant differences in gender,age,smoking history,age of dialysis before establishment of AVF,primary disease,Hb,serum creatinine(SCr),urea nitrogen(BUN),albumin(Alb),uric acid,PLT count,prothrombin time(PT),activated partial clotting enzyme live time(APTT),fibrinogen(Fib),D-dimers between the two groups(P>0.05).Patients in the indocybufen group had longer AVF median survival time than that in the aspirin group.Log-rank test showed that the long-term survival rate of AVF was higher in the indobufen group than in the aspirin group(P=0.018).The incidence of AVF dysfunction was lower in the indocybufen group than taht in the aspirin group(P=0.043).The number of AVF dysfunction caused by thrombosis in indocybufen group was lower than that in aspirin group(P=0.028).There was no significant difference in the number of adverse reactions between two groups(P=0.300).ConclusionIndobufen can effectively prevent AVF thrombosis in MHD patients,prolong the life of AVF,compare with aspirin,there were no difference in adverse reactions and the safety was better.
作者
杨瑶
于燕
李骏峰
沈建明
Yang Yao;Yu Yan;Li Junfeng;Shen Jianming(Jinzhou Medical University,Jinzhou 121001,China)
出处
《临床内科杂志》
CAS
2022年第3期177-180,共4页
Journal of Clinical Internal Medicine
作者简介
通讯作者:沈建明,E-mail:shmushjm@hotmail.com
