摘要
感染性关节炎是有病原微生物侵入关节而导致的疾病,多发于膝髋等大关节;致病菌主要为革兰氏阳性球菌。以往认为该病主要是由于血源性感染造成,而目前临床多见于创伤、关节穿刺、关节镜及人工关节置换术后感染。该疾病在中医学被称作"关节流注"或"骨痈疽",辨证早期属热毒内盛,血凝毒聚;后期属气血两虚。目前,感染性关节炎治疗主要以西医为主,包括局部或全身敏感抗生素应用及手术治疗等,疗效确切;缺点是致病菌因生物膜对抗生素产生抗性,使疾病迁延不愈。单纯中医药治疗已不多见,主要体现在现代医学治疗基础上,根据辨证分型予以中药内服及中药外治,其通过提高并调动机体免疫功能,清除细菌生物膜,进而促进关节感染的控制。文章将通过对近年来现代医学及中医学有关感染性关节炎临床研究的相关文献进行总结,了解目前中西医针对感染性关节炎的治疗及研究现状,进而为中医药治疗本病提供更多的研究思路。
Infectious arthritis is a disease caused by the invasion of pathogenic microorganisms into joints such as knee or hip,and the pathogenic bacteria are mainly gram-positive cocci.In the past,it was believed that this disease was hematogenous infection.However,it is now commonly seen after operation of joint trauma,articular puncture,arthroscope and joint replacement.In traditional Chinese medicine,infectious arthritis is known as“suppurative abscess of bones and joints”and“carbuncle of the bone”.According to the dialectics,the early stage is heat toxicity and blood agglomeration,and the later stage is deficiency of both Qi and blood.At present,the treatment of infectious arthritis is mainly based on Western medicine,including local or systemic sensitive antibiotic application and surgical treatment,and the curative effect is definite.However,the disadvantage is that the pathogenic bacteria are resistant to antibiotics owing to the bacterial biofilm formation,which makes the disease persist.Simple TCM treatment is rare now for this disease;on the basis of modern medical treatment,TCM mainly embodies the internal and external application according to the dialectical classification,which promotes the control of joint infection by improving the body’s immune function and clearing the bacterial biofilm.This article will summarize the relevant literatures of modern medicine and TCM on clinical research of infectious arthritis in recent years,thus understanding the current research status of TCM and Western medicine for this disease,so as to explore more research ideas for the treatment of this disease with traditional Chinese medicine.
作者
韩旭
于进洋
谭红略
HAN Xu;YU Jinyang;TAN Honglue(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Henan Orthopaedic Research Institute,Luoyang 471002,Henan,China;Henan University of Traditional Chinese Medicine,Zhengzhou 450046,Henan,China)
出处
《辽宁中医药大学学报》
CAS
2021年第9期74-78,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金联合基金(U1804189)
关键词
感染性关节炎
中医药
现代医学
研究进展
infectious arthritis
traditional Chinese medicine
modern medicine
research progress
作者简介
韩旭(1995-),男,河北衡水人,硕士研究生,研究方向:骨与关节疾病;通讯作者:谭红略(1971-),男,河南洛阳人,主任医师,硕士研究生导师,博士,研究方向:骨外科学。
