摘要
目的观察酪酸梭菌联合熊去氧胆酸对早产儿静脉营养相关性胆汁淤积的临床疗效。方法选取48例静脉营养相关性胆汁淤积早产儿,随机分为两组,对照组给予熊去氧胆酸;治疗组给予酪酸梭菌联合熊去氧胆酸,观察并记录两组患儿谷丙转氨酶、谷草转氨酶、胆汁酸、直接胆红素、间接胆红素变化情况及不良反应发生情况。结果治疗组的各项生化指标均优于对照组,差异有显著性(P<0.05),治疗组呕吐、腹泻发生情况均少于对照组,差异有显著性(P<0.05)。结论酪酸梭菌联合熊去氧胆酸可促进早产儿静脉营养相关性胆汁淤积转归,同时可减少不良反应的发生。
Objective To investigate the clinical efficacy of clostridium butyricum combined with ursodeoxycholic acid in the treatment of venous nutrition-related cholestasis in premature infants.Forty-eight cases of venous nutrition-related cholestasis premature infants were randomly divided into two groups.The control group was given ursodeoxycholic acid,and the treatment group was given Clostridium butyricum combined with ursodeoxycholic acid,the changes of alanine aminotransferase,aspartate aminotransferase,bile acid,direct bilirubin and indirect bilirubin,as well as the adverse reaction were observed and recorded.Results Compared with the control group,the biochemical parameters of the treatment group were lower than the control group,the difference was statistically significant(P<0.05).In the occurrence of adverse reactions,the incidence of vomiting and diarrhea in the treatment group was less than that in the control group,which has statistically significant difference(P<0.05).Conclusion Clostridium butyricum combined with ursodeoxycholic acid can promote the recovery of venous nutrition-related cholestasis in premature infants,and reduce the occurrence of adverse reactions.
作者
张俊杰
张立明
孟华夏
邱婷婷
闫琢
ZHANG Junjie;ZHANG Liming;MENG Huaxia;QIU Tingting;YAN Zhuo(Department of Pediatrics,Weifang Medical University,Weifang 261053,China;Department of Neonatology,Weifang People's Hospital)
出处
《潍坊医学院学报》
2020年第1期25-27,共3页
Acta Academiae Medicinae Weifang
关键词
酪酸梭菌
熊去氧胆酸
胃肠外营养
高直接胆红素血症
早产儿
极低出生体重儿
Clostridium butyricum
Ursodeoxycholic acid
Parenteral nutrition
High direct bilirubinemia premature infant
Very low birth weight
作者简介
张俊杰(1992年~),女,在读硕士研究生。主要研究方向:新生儿疾病;通讯作者:张立明,E-mail:13963659081@163.com
