摘要
目的探讨原发性颅内淋巴瘤的临床特点,总结立体定向活检结合放疗治疗原发性颅内淋巴瘤的疗效。方法本组17例怀疑为原发性颅内淋巴瘤的患者,术前均行CT及MRI检查,明确病变部位后,在MRI引导局麻下行立体定向病变活检术,术后一周拆线,病理报告回报后即行放疗。结果所有患者立体定向活检手术过程均顺利,手术时间均少于60min,出血量均少于50ml。立体定向活检手术的成功率100%,术后病理诊断均为弥漫性大B细胞淋巴瘤。术后一周拆线后即开始行放射治疗,出院随访时间1~3年,平均1.25年,随访发现生存期为6~36个月,中位生存期16.4月。结论MRI是诊断原发性颅内淋巴瘤的主要影像学手段,病理诊断是确诊的"金标准",立体定向活检结合放疗具有损伤小,风险低,患者生存时间长等优点,具有重要的临床应用价值。
Objective To explore the clinical characteristics of primary intracranial lymphoma and to summarize the effect on stereotactic biopsy combined with radiotherapy for the treatment of primary intracranial lymphoma.Methods 17 cases of suspected intracrainal lymphoma were enrolled in this group.All the patients underwent CT and MRI examination before the biopsy.After locating the lesion,MRI-guided stereotactic biopsy was performed under local anaesthesia.One week after the biopsy the suture was taken out.When the pathology result was comfirmed,radiotherapy was immediately initiated.Results The procedure of stereotactic biopsy in all patients was smoothly performed.The operative time was within 60 minutes,and the intraoperative bleeding volume was less than 50 miniliters.The successful rate of stereotactic biopsy was 100%.The post-operative pathology comfirmed the diognosis of diffuse large B cell lymphoma.Radiotherapy was immediately performed after the suture being removed in one week.The 1~3 years(mean 1.25 years)follow-up showed that the survival period was 6~36 months,and the median survival was 16.4 months.Conclusion MRI is the main diagnostic imaging method of primary intracranial lymphoma,and the pathology is the key standard of definite diagnosis.Stereotactic biopsy combined with radiotherapy has the advantage of less injury,small risk and longer survival.It is of important clinical application value.
作者
王焕明
胡飞
熊玉波
陈俊
肖恺
杨崇阳
涂圣旭
陈阳
Wang Huanming;Hu Fei;Xiong Yubo(Department of Neurosurgery,Wuhan Brain Hospital&Changhang General Hospital,Wuhan,430010,China.)
出处
《立体定向和功能性神经外科杂志》
2020年第3期141-144,共4页
Chinese Journal of Stereotactic and Functional Neurosurgery
关键词
立体定向活检
放疗
原发性颅内淋巴瘤
Stereotactic biopsy
Radiotherapy
Primary intracranial lymphoma
