摘要
目的:应用两样本MR方法挖掘211种肠道菌群对男性生殖与性健康的因果关系。方法:采用MiBioGen联盟发布的全基因组关联研究(GWAS)相关遗传变异数据作为肠道菌群的工具变量(IVs),芬兰生物样本库GWAS相关遗传变异数据分别作为男性不育症、畸形精子症、性功能障碍、勃起功能障碍、睾丸功能障碍的IVs。使用逆方差加权法作为MR分析方法,根据效应指标优势比和95%置信区间评估结果,并进行数据敏感性分析。结果:分别发现6种与男性不育症相关、12种与畸形精子症相关、5种与性功能障碍相关、4种与勃起功能障碍、4种与睾丸功能障碍有关的肠道菌群,且数据敏感性分析无异常,因果方向均正确。结论:肠道菌群与男性生殖与性健康密切相关。
Objective:The purpose of this study was to use the MR method to explore the causal relationship between 211 gut microbiota and male reproductive and sexual health.Methods:The MiBioGen alliance published genome-wide association study(GWAS)related genetic variation data was used as instrumental variables(IVs)for gut microbiota,and the Finngen biobank GWAS related genetic variation data was used as IVs for male infertility,abnormal sperm,sexual dysfunction,erectile dysfunction,and testicular dysfunction.The inverse variance-weighted(IVW)method was used as the MR analysis method,the results were evaluated according to the odds ratio and 95%confidence interval of the effect measures,and data sensitivity analysis was performed.Results:The results showed that 6 types of gut microbiota were related to male infertility,12 types were related to abnormal sperm,5 types were related to sexual dysfunction,4 types were related to erectile dysfunction,and 4 types were related to testicular dysfunction.And there was no abnormality in the data sensitivity analysis.Conclusion:The intestinal microbiota is closely related to male reproductive and sexual health.
作者
马思成
张宸铭
郝晓慧
马瑞敏
胡静
于雯霖
王祖龙
孙自学
MA Si-cheng;ZHANG Chen-ming;HAO Xiao-hui;MA Rui-min;HU Jing;YU Wen-lin;WANG Zu-long;SUN Zi-xue(Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China;Department of Andrology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450003,China;Department of Reproductive Medicine,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450002,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2023年第7期587-595,共9页
National Journal of Andrology
基金
国家自然科学基金(82174377)
中国博士后科研基金第16批特别资助(2023T160201)
中国博士后基金面上项目(2022M721068)
国家中医临床研究基地科研专项(2021JDZX2056)
河南省高等学校重点科研项目计划(23A360005)
河南省重点研发与推广专项(232102311199)
国家级大学生创新创业训练计划(202210471022,202310471011)
关键词
孟德尔随机化研究
肠道菌群
全基因组关联研究
男性不育
男性生殖健康
mendelian randomization study
intestinal microbiota
genome-wide association study
male infertility
male reproductive health
作者简介
马思成(2002-),男,河南新蔡县人,医师,硕士研究生,从事中医药防治生殖系统疾病研究。Email:1025482806@qq.com;通讯作者:张宸铭,Email:zcmhnzy@163.com
