摘要
前列腺癌是男性泌尿生殖系统中常见的肿瘤之一,在我国的发病率和死亡率正日趋升高,成为重要的公共健康问题。近来,有研究表明自噬在包括癌症等许多疾病过程中都起着重要的病理生理作用。与此同时,部分miRNA也已经成为前列腺癌细胞中调节自噬的关键因子,并在前列腺癌发生、发展以及诊疗过程中起重要作用。深入研究miRNA将有利于发现一些有价值的诊断和新型治疗方法。因此,本文就自噬相关的miRNA在前列腺癌中作用的研究进展做一综述,为前列腺癌的诊疗提供参考。
Prostate cancer(PCa)is one of the common tumors in the genitourinary system,with an increasing morbidity and mortality in China.Recent studies show that autophagy plays an important pathophysiological role in many diseases,including cancers.Besides,some miRNAs are also key regulatory factors for autophagy in PCa cells,and play an important role in the development,progression,diagnosis and treatment of PCa.In-depth studies of miRNAs may contribute to the discovery of some valuable diagnostic methods and novel treatment strategies.This article reviews the progress in researches on the role of autophagy-related miRNAs in PCa,aiming to provide some reference for the diagnosis and treatment of the malignancy.
作者
马梦飞(综述)
胡隽(综述)
许松(审校)
MA Meng-fei;HU Jun;XU Song(Jinling School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210002,China;Jinling School of Clinical Medicine,Nanjing Medical University,Nanjing,Jiangsu 210002,China;Depart-ment of Urology,Jinling Hospital Affiliated to Nanjing University School of Medicine/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)
出处
《中华男科学杂志》
CAS
CSCD
2024年第1期77-82,共6页
National Journal of Andrology
作者简介
马梦飞(1999-),男,河南驻马店市人,硕士研究生,从事泌尿外科及男科专业;通讯作者:许松,Email:1930306530@qq.com
