摘要
目的分析原发性肾病综合征(PNS)患儿血清可溶性髓系细胞触发受体-1(sTREM-1)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)、TOLL样受体4(TLR4)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平与肾功能的关系。方法选择2018年7月—2020年7月本院收治的63例PNS患儿与同期体检的60名健康儿童作为研究对象,PNS患儿纳入观察组,健康儿童纳入对照组。比较两组患儿血清sTREM-1、suPAR、TLR4、NGAL水平,比较不同疾病病情程度、患儿血清sTREM-1、suPAR、TLR4、NGAL及肾功能指标[血肌酐(Scr)、血尿素氮(BUN)与24 h尿蛋白定量],分析血清sTREM-1、suPAR、TLR4、NGAL与肾功能指标的相关性。结果观察组血清sTREM-1、suPAR、TLR4、NGAL指标水平均明显高于对照组(P<0.05)。重度PNS患儿血清sTREM-1、suPAR、TLR4、NGAL、SCr、BUN以及24 h尿蛋白定量水平高于中度PNS患儿,中度PNS患儿上述指标高于轻度PNS患儿(P<0.05)。PNS患儿血清sTREM-1、suPAR、TLR4、NGAL水平与BUN、SCr以及24 h尿蛋白定量水平均呈正相关(P<0.05)。结论血清sTREM-1、suPAR、TLR4、NGAL水平在PNS患儿中异常升高,且上述指标越高,PNS患儿肾功能损伤程度越严重,或可作为评估PNS患儿病情的辅助参考指标。
Objective To analyze the relationship between serum levels of soluble triggering receptor-1(sTREM-1),soluble urokinase type plasminogen activator receptor(suPAR),toll like receptor 4(TLR4),neutrophil gelatinase associated lipocalin(NGAL)and renal function in child patients with primary nephrotic syndrome(PNS).Methods 63 child patients with PNS who were treated in our hospital from July 2018 to July 2020 were selected as the research objects,they were included in the observation group,another 60 healthy children were selected as the control group.The serum levels of sTREM-1,suPAR,TLR4,NGAL in the two groups of children were compared between the serum sTREM-1,suPAR,TLR4,NGAL and renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN)and 24 h urinary protein quantification]in child patients with different disease severity were compared between the two groups,the correlation between serum sTREM-1,suPAR,TLR4,NGAL and renal function was analyzed.Results The serum levels of sTREM-1,suPAR,TLR4,NGAL in the observation group were significantly higher than those of the control group(P<0.05).The serum levels of sT REM-1,suP AR,TLR4,NGAL,Scr,BUN and 24-hour urine protein were higher in child patients with severe PNS than those of child patients with moderate PNS,the above indexes were higher in child patients with moderate PNS than those of child patients with mild PNS(P<0.05).Serum levels of sT REM-1,suP AR,TLR4,NGAL were positively correlated with BUN,Scr and 24-hour urinary protein in child patients with PNS(P<0.05).Conclusions Serum levels of sT REM-1,suP AR,TLR4,NGAL were abnormally elevated in child patients with PNS,the higher the above indexes,the more serious the renal function damage of PNS children,which may be used as an auxiliary reference index to evaluate the condition of child patients with PNS.
作者
尤鑫
温瑞
戚润鹏
谢辉
YOU Xin(Department of clinical laboratory,people's hospital of Henan University of traditional Chinese medicine,Zhengzhou people's hospital,Zhengzhou,Henan,450000,China)
出处
《齐齐哈尔医学院学报》
2021年第9期757-759,共3页
Journal of Qiqihar Medical University
基金
河南省医学教育研究项目(wjlx2018286)
作者简介
通信作者:尤鑫,Email:youzzjkh@163.com
