摘要
目的探讨高效抗逆转录病毒治疗(HARRT)对艾滋病合并淋巴瘤患者远期预后的影响。方法研究共纳入2012年8月-2015年7月在新疆医科大学第八附属医院住院治疗的86例艾滋病合并淋巴瘤患者,按是否接受HARRT治疗将患者分为HARRT组和N-HARRT组,比较两组患者一般临床病理资料,Kaplan-Meier生存分析比较两组患者疾病无进展生存率和总生存率,采用单因素和多因素Cox回归分析获得影响艾滋病合并淋巴瘤患者远期预后的独立预测因子。结果两组艾滋病合并淋巴瘤患者一般临床病理资料比较,差异均无统计学意义(P>0.05)。Kaplan-Meier生存分析显示,HARRT组患者1、3、5年疾病无进展生存率显著高于N-HARRT组(93.4%、62.1%、51.3%vs.83.4%、38.4%、31.2%),HARRT组患者1、3、5年总生存率显著高于N-HARRT组(100.0%、73.1%、53.5%vs.95.2%、51.4%、36.8%),差异均有统计学意义(P<0.05)。多因素Cox回归分析显示,基线CD4+T淋巴细胞计数、淋巴瘤临床分期、LDH升高以及HARRT为影响艾滋病合并淋巴瘤患者疾病无进展生存的独立预测因素,ECOG评分、基线CD4+T淋巴细胞计数、淋巴瘤临床分期以及HARRT为影响艾滋病合并淋巴瘤患者总生存情况的独立预测因素。结论HARRT可改善艾滋病合并淋巴瘤患者疾病无进展生存率和总生存率,值得临床推广应用。
Objective To investigate the effect of highly active antiretroviral therapy(HARRT)on the long-term prognosis of AIDS patients with lymphoma.Methods A total of 86 AIDS patients with lymphoma hospitalized in the 8th Affiliated Hospital of Xinjiang Medical University from August 2012 to July 2015 were included in the study.According to whether they received HARRT treatment,the patients were divided into HARRT group and N-HARRT group.The general clinicopathological data of the two groups were compared.The progression free survival rate and overall survival rate of the two groups were compared by Kaplan-Meier survival analysis.Univariate and multivariate Cox regression analysis were used to obtain independent predictors of the long-term prognosis of AIDS patients with lymphoma.Results There was no significant difference in general clinicopathological data between the two groups(P>0.05).Kaplan-Meier survival analysis showed that the 1,3 and 5-year disease progression free survival rates of patients in the HARRT group were significantly higher than those in the N-HARRT group(93.4%,62.1%,51.3%vs.83.4%,38.4%,31.2%,P<0.05),the 1,3 and 5-year overall survival rates of patents in the HARRT group were significantly higher than those in the N-HARRT group(100.0%,73.1%,53.5%vs.95.2%,51.4%,36.8%,P<0.05).Multivariate Cox regression analysis showed that baseline CD4+T lymphocyte count,lymphoma clinical stage,increased LDH and HARRT were independent predictors of disease progression free survival of AIDS patients with lymphoma.ECOG score,baseline CD4+T lymphocyte count,clinical stage of lymphoma and HARRT were independent predictors of overall survival of AIDS patients with lymphoma.Conclusion HARRT could improve the progression free survival rate and overall survival rate of AIDS patients with lymphoma,which was worthy of clinical application.
作者
马合木热·艾则孜
哈力木拉提·阿布都沙拉木
MAHEMURE Aizezi;HALIMULATI Abudushalamu(Department of Infection,the Eighth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830001,China)
出处
《热带医学杂志》
CAS
2022年第8期1074-1078,共5页
Journal of Tropical Medicine
基金
国家科技重大专项课题(2018ZX10302104)
作者简介
马合木热·艾则孜(1980-),女,硕士,副主任医师,研究方向:传染病(艾滋病为主)的诊治及相关研究;通信作者:哈力木拉提·阿布都沙拉木,E⁃mail:stevenshoney@163.com
