摘要
目的探讨多发性骨髓瘤(MM)患者CD56和CD117的不同表达模式与疾病临床特征及预后的关系。方法根据流式结果CD56/CD117的表达模式将50例初发MM患者分为双阴组(CD56-CD117-)(n=21)、双阳组(CD56+CD117+)(n=4),CD56阳组(n=20)和CD117阳组(n=5),分析各组患者的一般资料、临床特征、实验室检查结果及预后。结果双阴组骨损害发生率56.8%,均高于双阳组(10.8%)、CD56阳组(32.4%)和CD117阳组(0.0%),差异均有统计学意义(P均<0.0083)。双阴组β2微球蛋白(β2-MG)和肌酐(Crea)水平低于CD117阳组(5.6 mg/L vs.12.2 mg/L;110.0μmol/L vs.469.0μmol/L),CD56阳组Crea水平明显低于CD117阳组(97.5μmol/L vs.469.0μmol/L),差异均有统计学意义(P<0.0083);双阴组免疫固定电泳IgA-L和IgG-K发生率高于CD56阳组,而IgG-L和轻链发生率低于CD56阳组,差异均有统计学意义(P均<0.0083);CD117阳组的IGH重排发生率(80.00%)明显高于双阴组(4.76%),差异均有统计学意义(P<0.0083);四组间国际分期系统(ISS)预后分期差异无统计学意义(P>0.05)。结论CD56和CD117的不同表达模式与MM患者的临床特征密切相关,可提示其预后。
Objective To investigate the relationship between the different expression patterns of CD56/CD117 and the clinical features or prognosis in patients with multiple myeloma(MM).Methods According to the expression pattern of CD56/CD117,50 patients with primary MM were divided into four groups,including 21 cases in the double-negative group(CD56-CD117-),4 cases in the double-positive group(CD56+CD117+),20 cases in the CD56 positive group and 5 cases in the CD117 positive group.The general data,clinical features,laboratory data and prognosis of patients were analyzed.Results The incidence of bone damage in the double-negative group was much higher than that in the double-positive group,CD56 positive group and CD117 positive group(56.8%vs.10.8%,32.4%,0.0%)(P<0.0083).The levels of Beta-2-microglobulin(β2-MG)and creatinine(Crea)in the double-negative group were significantly lower than those in CD117positive group(5.6 mg/L vs.12.2 mg/L;110.0μmol/L vs.469.0μmol/L)(P<0.0083).The Crea level of the CD56 positive group was significantly lower than that of the CD117 positive group(97.5μmol/L vs.469.0μmol/L)(P<0.0083).In the immunofixation electrophoresis,the probability of IgA-L and IgG-K of the double negative group was higher than that of the CD56 positive group,while the probability of IgG-L and the light chain was lower than that of the CD56 positive group(P<0.0083).The incidence of IGH rearrangement in the CD117 positive group(80.00%)was significantly higher than that in the double negative group(4.76%)(P<0.0083).There was no significant difference in the International Staging System(ISS)stage among the four groups(P>0.05).Conclusion The different expression patterns of CD56/CD117 were closely related to the clinical features of MM patients,which might indicate their prognosis.
作者
陈炜烨
韩丽乔
梁恩瑜
涂晓欣
欧阳芬
陈康艺
黄宪章
庄俊华
柯培锋
徐建华
CHEN Wei-ye;HAN Li-qiao;LIANG En-yu;TU Xiao-xin;OU Yang-fen;CHEN Kang-yi;HUANG Xian-zhang;ZHUANG Jun-hua;KE Pei-feng;XU Jian-hua(Department of Laboratory Medicine,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine),Guangzhou,Guangdong 510120;Department of Laboratory Medicine,Nanhai Hospital of Guangdong Provincial People's Hospital,Foshan,Guangdong 528200;Shunde Hospital of Guangzhou University of Chinese Medicine,Foshan,Guangdong 528333,China)
出处
《热带医学杂志》
CAS
2022年第9期1252-1257,共6页
Journal of Tropical Medicine
基金
广东省中医院拔尖人才科研专项资助(BJ2022KY04)
广东省中医院中医药科学技术研究专项(YN2019QL06)
广东省基础与应用基础研究基金(2021A1515220149)
广东省中医药局科研项目(20202070)
作者简介
陈炜烨(1983-),男,硕士,主管技师,从事临检血液的诊断、教学工作;通信作者:柯培锋,E-mail:kevinland020@163.com;通信作者:徐建华,E-mail:jhxu1976@126.com
