摘要
目的评估联合检测外周血中未成熟粒细胞(IG)、高荧光强度淋巴细胞(HFLC)和C反应蛋白(CRP)对新生儿败血症诊断的价值。方法选取广州市妇女儿童医疗中心2017年9月至2018年12月住院的110例有感染中毒症状的新生儿作为研究对象,其中败血症组48例,局部感染组62例。另选取60名同期健康体检的新生儿作为健康对照组。应用受试者工作特征(ROC)曲线评价IG%、HFLC%、CRP诊断新生儿败血症的效能。结果败血症组IG明显高于局部感染组和健康对照组,差异有统计学意义(P<0.05)。HFLC与CRP在败血症组和局部感染组间比较差异无统计学意义(P>0.05),而健康对照组的IG、HFLC、CRP三项参数均明显低于其他两组,差异有统计学意义(P<0.05)。三项参数联合诊断,ROC曲线下面积(AUC)达到0.898,敏感度为76.70%,特异度为87.50%,阳性预测值为0.742,阴性预测值为0.881。结论联合检测新生儿外周血中IG%、HFLC%和CRP对新生儿败血症早期诊断、早期合理用药干预具有重要参考价值。
Objective To investigate the clinical diagnostic values of immature granulocytes(IG),high fluorescent lymphocyte(HFLC)and C-reactive protein(CRP)in neonatal sepsis.Methods A prospective study was conducted on110 neonates with sepsis hospitalized in Guangzhou women and children’s medical center from September 2017 to December2018.According to the guidelines for diagnosis and management of neonatal sepsis,48 cases were enrolled in the sepsis group and 62 cases were enrolled in the local infection group.In addition,60 newborns in the same period of health examination were selected as the healthy control group.The diagnostic values of IG%,HFLC%and CRP in neonatal sepesis were evaluated with the receiver operating characteristic(ROC)analysis.Results The IG%in the sepsis group was significantly higher than the local infection group and the healthy control group(P<0.05).There was no significant difference of HFLC%and CRP between the sepsis group and the local infection group(P>0.05),while the three parameters in the healthy control group were significantly lower than the other two groups(P<0.05).The area under the ROC curve of IHC was 0.898,the sensitivity and the specificity were 76.70%,87.50%respectively;the positive prediction value and the negative prediction value were 0.742 and 0.881,respectively.Conclusion The combined detection of IG%,HFLC%and CRP in the peripheral blood of neonates with clinical significance for the early diagnosis of neonatal sepsis and early rational drug intervention.
作者
梁肖云
杨春妍
郑浩
李文利
鲍丽娟
汪道文
梁秉绍
周珍文
LIANG Xiao-yun;YANG Chun-yan;ZHENG Hao;LI Wen-li;BAO Li-juan;WANG Dao-wen;LIANG Bing-shao;ZHOU Zhen-wen(Department of Clinical Laboratory,Guangzhou Women and Children's Medical Center,Guangzhou,Guangdong 510120,China)
出处
《热带医学杂志》
CAS
2022年第10期1414-1417,1461,共5页
Journal of Tropical Medicine
基金
建设中医药强省立项(20151052)
作者简介
梁肖云(1969-),主任技师,本科,研究方向:临检血液学;通信作者:周珍文,E-mail:zzw6248@126.com
