摘要
目的分析玉林地区住院患者肺炎链球菌感染的流行病学特点及耐药性变迁,为临床有效预防和治疗肺炎链球菌感染提供流行病学信息。方法分析2015-2021年在玉林市第一人民医院住院患者中分离的肺炎链球菌,对其细菌分布、感染的流行特点及药物敏感性进行分析。结果2015-2021年共分离出肺炎链球菌1741株,以痰液标本居多占92.02%(1602/1741),儿科分离率占比最高为58.59%(1020/1741),其中以0~5岁儿童为主。感染流行的季节有显著差异,以春季感染多见,占28.60%(498/1741)。男性分离率为68.75%,明显高于女性的31.25%。肺炎链球菌对红霉素和四环素的耐药率处于较高水平均≥91.60%,对青霉素的耐药率一直保持最低水平;肺炎链球菌对阿莫西林、头孢曲松和头孢噻肟的耐药率由52.20%、36.10%、36.60%下降至4.20%、16.80%、18.50%。儿科分离的肺炎链球菌耐药率最高。不同人群的肺炎链球菌耐药率以>5~14岁儿童最高,>59岁老年人的耐药率最低。结论本地区住院患者肺炎链球菌感染以儿童和老年人为主,其中季节、性别和年龄是重要的易感因素,分离自不同年龄段和科室的菌株对抗生素的耐药性相差较大。因此有必要继续开展病原菌感染的流行特点及耐药性监测,为感染控制及治疗提供依据。
Objective The epidemiological characteristics and drug resistance of Streptococcal pneumoniae infection in hospitalized patients in Yulin area were studied,and epidemiological information was provided for the effective prevention and treatment of Streptococcus pneumoniae infection.Methods The isolated Streptococcus pneumoniae from hospitalized patients in 2015-2021 was retrospectively analyzed for the distribution,epidemic characteristics of infection,and drug sensitivity.Results From 2015 to 2021,1741 strains of Streptococcus pneumoniae were isolated;most of which were sputum samples,accounting for 92.02%(1602/1741),and the highest isolation rate in pediatrics was 58.59%(1020/1741),mainly children 0-5 years old.There were significant differences in the epidemic seasons of infection,with 28.60%(498/1741)in spring.The infection rate of male patients was 68.75%,which was significantly higher than that of female patients 31.25%.The resistance rates of Streptococcus pneumoniae to erythromycin and tetracycline were higher than 91.60%,and the resistance rate to penicillin remained at the lowest level.The resistance rates of Streptococcus pneumoniae to amoxicillin,ceftriaxone and cefotaxime were 52.20%,36.10%and 36.60%to 4.20%,16.80%and 18.50%,respectively.The drug resistance rate of Streptococcus pneumoniae isolated from pediatrics was the highest.The drug resistance rate of Streptococcus pneumoniae in different populations was the highest in children aged>5~14 years and the lowest in the elderly aged>59 years.Conclusions Streptococcal pneumoniae infections in hospitalized patients in this region were predominantly in children and the elderly;of which,season,sex and age were important predisposing factors,and the resistance of strains to antimicrobial drugs from different ages and departments varied greatly.Therefore,it was necessary to continue to carry out epidemiological characteristics and drug resistance monitoring of pathogenic infections to provide a basis for infection control and treatment.
作者
丘丹萍
李泰阶
王柏莲
李明强
薛野
覃美香
梁婵
QIU Danping;LI Taijie;WANG Bailian;LI Mingqiang;XUE Ye;QIN Meixiang;LIANG Chan(Department of Laboratory Medicine,Yulin First People's Hospital,Yulin,Guangxi 537035,China; Department of Laboratory Medicine,Wuming Hospital of Guangxi Medical University,Nanning,Guangxi 530199,China)
出处
《热带医学杂志》
CAS
2023年第7期1015-1019,共5页
Journal of Tropical Medicine
基金
广西壮族自治区卫生健康委科研课题(Z20200348)
广西高校中青年教师科研基础能力提升项目(2021KY0121)
南宁市武鸣区科学研究与技术开发计划项目(20190408)
玉林市科学研究与技术开发计划项目(玉市科20204303)
关键词
肺炎链球菌
流行病学特点
耐药性
Streptococcus pneumoniae
Epidemiological characteristics
Drug resistance
作者简介
丘丹萍(1985-),女,硕士,副主任技师,主要从事病原微生物流行病学与耐药机制研究;通信作者:李泰阶,E-mail:nicesown@163.com
