摘要
目的分析武威市区域内救治创伤后患者白介素-10(IL-10)、C-反应蛋白(CRP)、降钙素原(PCT)水平与预后的相关性。方法选取2022年1月-2023年6月甘肃省武威肿瘤医院急诊科收治的武威市区域内创伤患者180例作为研究对象,按照患者预后情况分为预后良好组(149例)和预后不良组(31例),收集并比较两组患者一般临床资料及IL-10、CRP、PCT水平,比较两组急性生理与慢性健康(APACHEⅡ)评分及创伤严重程度评分量表(ISS)评分,采用Pearson相关模型分析创伤患者IL-10、CRP、PCT与APACHEⅡ评分及ISS评分的相关性,绘制受试者工作特征曲线(ROC)分析IL-10、CRP、PCT预测患者不良预后的应用价值。结果预后不良组IL-10、CRP、PCT水平均高于预后良好组,APACHEⅡ及ISS评分均高于预后良好组,差异均有统计学意义(t=7.338、8.566、9.406、15.896、15.168,P均<0.05)。Pearson相关性分析显示,IL-10、CRP、PCT与APACHEⅡ均成正相关(r=0.879、0.725、0.914,P均<0.05),与ISS评分均成正相关(r=0.831、0.863、0.847,P均<0.05)。ROC曲线分析结果显示,IL-10、CRP、PCT预测患者不良预后的曲线下面积(AUC)分别为0.815、0.877、0.839,而三者联合检测的AUC为0.947,高于单一检测(P<0.05)。结论IL-10、CRP、PCT水平与创伤后患者预后有关,联合检测其水平对于预测患者不良预后具有较好的应用价值,可为临床辅助诊断患者病情提供参考依据。
Objective To analyze the correlation between the levels of interleukin-10(IL-10),C-reactive protein(CRP),procalcitonin(PCT)and the prognosis of patients after trauma.Methods A total of 180 patients with trauma admitted to the Emergency Department of the Wuwei Tumor Hospital of Gansu Province from January 2022 to December 2022 were selected as the research objects.According to the prognosis of patients,they were divided into good prognosis group(149 cases)and poor prognosis group(31 cases).The general clinical data and levels of IL-10,CRP and PCT were collected and compared between the two groups.The acute physiology and chronic health evaluationⅡ(APACHEⅡ)score and injury severity score(ISS)were compared between the two groups.Pearson correlation model was used to analyze the correlation between IL-10,CRP,PCT and APACHEⅡscore and ISS score in trauma patients.The receiver operating characteristic(ROC)curve was drawn to analyze the application value of IL-10,CRP and PCT in predicting the poor prognosis of patients.Results The levels of IL-10,CRP and PCT in the poor prognosis group were higher than those in the good prognosis group,and the APACHEⅡand ISS scores were higher than those in the good prognosis group(t=7.338,8.566,9.406,15.896,15.168;all P<0.05).Pearson correlation analysis showed that IL-10,CRP and PCT were positively correlated with APACHEⅡ(r=0.879,0.725,0.914;all P<0.05),and positively correlated with ISS score(r=0.831,0.863,0.847;all P<0.05).The results of ROC curve analysis showed that the areas under the curve(AUC)of IL-10,CRP and PCT in predicting the poor prognosis of patients were 0.815,0.877 and 0.839,respectively,while the AUC of combined detection of the three was 0.947,which was higher than that of single detection(P<0.05).Conclusions The levels of IL-10,CRP and PCT were related to the prognosis of patients after trauma.The combined detection of their levels had a good application value in predicting the poor prognosis of patients,and could provide a reference for clinical diagnosis of patients.
作者
张振帅
宋亚平
罗永生
梁泽东
ZHANG Zhenshuai;SONG Yaping;LUO Yongsheng;LIANG Zedong(Department of Emergency,Gansu Wuwei Academy of Medical Sciences,Wuwei Tumor Hospital of Gansu Province,Wuwei,Gansu 733000,China)
出处
《热带医学杂志》
CAS
2023年第11期1601-1604,共4页
Journal of Tropical Medicine
基金
甘肃省科技重点研发项目(21YF5FH212)
武威市市级科技计划项目(科技人才和科学普及计划)(WW2202RPZ035)
作者简介
张振帅(1982-),男,本科,副主任医师,研究方向为急诊医学,E-mail:934138494@qq.com
