摘要
目的:运用古今医案云平台挖掘真实世界中医药治疗小儿疳积的用药规律。方法:收集2021年1月—2021年10月广东省中医院儿科门诊病案资料,运用统计、关联规则、复杂网络分析等数据挖掘方法分析中医药治疗小儿疳积的用药规律。结果:共纳入216个医案,处方216首,涉及中药193味。小儿疳积主要临床证型有肝旺脾虚证、脾虚湿困证、虚实夹杂证、脾肺两虚证等。中医药治疗小儿疳积高频药物有白术、甘草、茯苓、白芍、芒果核、陈皮等;治疗中药的药性为平、温性为主,以甘、苦、辛、酸味多见,多归于脾、胃、肺、肝经。关联分析得出常用药物组合有白术-甘草、白术-茯苓、甘草-茯苓等。聚类分析得到防风-陈皮-木香、鸡内金-山药-柿蒂-砂仁-孩儿草-糯稻根、甘草-白术-茯苓、麦芽-白芍-芒果核-布渣叶-莱菔子-钩藤-山楂-稻芽4个组合。复杂网络分析核心处方为白术-甘草-茯苓-白芍-芒果核-陈皮-布渣叶-莱菔子-山楂-稻芽-麦芽-砂仁-钩藤-柿蒂。结论:中医药治疗小儿疳积以健脾消食、柔肝为主要治法,辅以行气化湿,临床常采用木香顺气散、四君子汤、保和丸等加减方辨证治疗。
Objective:To explore the medication rules of Chinese medicine for treating infantile malnutrition in the real world with the Ancient and Modern Medical Records Cloud Platform.Methods:Medical record data from the Outpatient Department of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to October 2021 were collected to analyze the medication rules of Chinese medicine in the treatment of infantile malnutrition with statistics,association rules,complex network analysis and other data mining methods.Results:A total of 216 medical records and 216 prescriptions were included,involving 193 kinds of Chinese medicinals.The main clinical syndrome types of infantile malnutrition were the liver hyperactivity and spleen deficiency syndrome,the spleen deficiency leading to damp encumbrance syndrome,the deficiency-excess complex syndrome,and the dual deficiency of the spleen-lung syndrome.In the Chinese medicine treatment for infantile malnutrition,Chinese medicinals with highfrequency usage were Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix et Rhizoma,Poria,Paeoniae Radix Alba,Citri Reticulatae Pericarpium,Mangifera Indica Kernels,etc.The nature of the Chinese medicinals was mainly balanced and warm;the main flavors were sweet,bitter,acrid,and sour;the main meridian entries were the spleen meridian,the stomach meridian,the lung meridian,and the liver meridian.Association analysis showed that commonly used medicine combinations included Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma,Atractylodis Macrocephalae Rhizoma-Poria,Glycyrrhizae Radix et Rhizoma-Poria,etc.Four combinations were found by association analysis,namely Saposhnikoviae Radix-Citri Reticulatae Pericarpium-Aucklandiae Radix,Galli Gigerii Endothelium Corneum-Dioscoreae Rhizoma-Kaki Calyx-AmomI Fructus-Rungia pectinata-Radix Oryzae Glutinosae,Glycyrrhizae Radix et Rhizoma-Poria-Atractylodis Macrocephalae Rhizoma,and Hordei Fructus Germinatus-Paeoniae Radix Alba-Mangifera Indica Kernels-Microctis Folium-Raphani Semen-Uncariae Ramulus Cum Uncis-Crataegi Fructus-Oryzae Fructus Germinatus.Complex network analysis showed that the core prescription included Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma-Poria-Paeoniae Radix Alba-Mangifera Indica Kernels-Citri Reticulatae Pericarpium-Microctis Folium-Raphani Semen-Crataegi Fructus-Oryzae Fructus Germinatus-Hordei Fructus Germinatus-AmomI Fructus-Uncariae Ramulus Cum Uncis-Kaki Calyx.Conclusion:The main treatment methods of Chinese medicine for infantile malnutrition are fortifying the spleen and promoting digestion and softeining the liver,which is assisted by the method of moving qi and removing dampness.In the clinical practice,syndrome differentiation and treatment is usually carried out with modified Muxiang Shunqi Powder,Sijunzi Decoction,Baohe Pills,etc.
作者
黄镛
李成辉
王琳
朱晨
HUANG Yong;LI Chenghui;WANG Lin;ZHU Chen(Department of Pharmacy,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Traditional Chinese Medicine),Guangzhou Guangdong 510120,China;Internal Medicine Department,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Traditional Chinese Medicine),Guangzhou Guangdong 510120,China)
出处
《新中医》
CAS
2023年第13期52-57,共6页
New Chinese Medicine
关键词
小儿疳积
真实世界
数据挖掘
用药规律
Infantile malnutrition
Real world
Data mining
Medication rules
作者简介
黄镛(1988-),女,主管中药师,E-mail:89203979@qq.com;通信作者:李成辉(1985-),男,主治医师,E-mail:lichenghui1985@126.com。
