摘要
目的探讨高血压性脑出血患者亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点基因多态性与其血清叶酸、维生素B12、同型半胱氨酸水平及与预后的相关性。方法选取2021年1月至2023年2月于佛山市南海区人民医院住院治疗的171例HCH患者为研究对象,收集患者血清叶酸、维生素B12和同型半胱氨酸水平及MTHFR C677T基因多态性。在入院时和入院2周时测量患者脑水肿体积,并于发病后6个月使用mRS评分评价患者预后。结果171例患者中,MTHFR基因C677T位点基因型分布:CC型29例、CT型59例、TT型83例。TT组血清叶酸、维生素B12水平低于CC组和CT组,同型半胱氨酸水平高于CC组和CT组(P<0.05);CT组血清叶酸、维生素B12水平低于CC组,同型半胱氨酸水平高于CC组(P<0.05)。(3)TT组入院2周时脑水肿体积大于CC组和CT组,CT组大于CC组(P<0.05)。(4)CC组患者预后良好比例显著高于CT组和TT组(P<0.05)。结论MTHFR基因C677T多态性与HCH患者血清叶酸、维生素B12、同型半胱氨酸水平相关,CT和TT型患者预后较差。
Objective:To explore the correlation between the C677T site gene polymorphism of methylenetetra-hydrofolate reductase(MTHFR)gene and serum folate,vitamin B12,homocysteine levels,as well as prognosis in patients with hypertensive intracerebral hemorrhage.Methods:A total of 171 HCH patients hospitalized in Nanhai District People's Hospital of Foshan City from January 2021 to February 2023 were selected as the study objects.Serum levels of folate,vitamin B12,homocysteine and MTHFR C677T gene polymorphisms were collected.The cerebral edema volume was measured at admission and 2 weeks after admission,and the prognosis was evaluated by mRS Score 6 months after the onset of the disease.Results:(1)Among 171 patients,the genotype distribution of MTHFR gene C677T locus was found in 29 cases of CC type,59 cases of CT type,and 83 cases of TT type.(2)The levels of serum folate and vitamin B12 in the TT group were significantly lower than those in the CC and CT groups,while the levels of homocysteine were significantly higher than those in the CC and CT groups(P<0.05);The levels of serum folate and vitamin B12 in the CT group were significantly lower than those in the CC group,and the levels of homocysteine were significantly higher than those in the CC group(P<0.05).(3)At 2 weeks of admission,the volume of cerebral edema in the TT group was significantly larger than that in the CC and CT groups,and the CT group was significantly larger than that in the CC group,with a statistically significant difference(P<0.05).(4)The proportion of patients with good prognosis in the CC group was significantly higher than that in the CT group and TT group(P<0.05).Conclusion:MTHFR gene C677T polymorphism is associated with serum folate,vitamin B12,and homocysteine levels in HCH patients.CT and TT type patients have poor prognosis.
作者
袁晓文
冯广荣
张欣
关幼华
朱翠珍
刘春林
黄德兵
Yuan Xiaowen;Feng Guangrong;Zhang Xin;Guan Youhua;Zhu Cuizhen;Liu Chunlin;Huang Debing(Laboratory Department of Nanhai District People's Hospital,FoshanCity,Gruangdong Province,528200;Pediatrics Departmentof Nanhai District People's Hospital,FoshanCity,Gruangdong Province,528200;Emergency Department of Nanhai District People's Hospital,FoshanCity,Gruangdong Province,528200)
出处
《生命科学仪器》
2023年第4期50-52,共3页
Life Science Instruments
基金
佛山市自筹经费科技项目(2220001004881)
作者简介
通讯作者:袁晓文
