摘要
目的:分析桃红四物汤加减辅助手术治疗对四肢骨折患者术后肢体运动功能、骨代谢指标及其预后的影响。方法:选取2019年9月~2020年9月遂宁市中医院收治的四肢骨折患者96例作为研究对象,采用信封法随机分为观察组(48例)及对照组(48例)。两组患者均予以切开复位内固定术,术后对照组采用抗感染等常规治疗,观察组在对照组基础上加用桃红四物汤加减治疗,两组均治疗2周。比较两组治疗前后骨代谢指标[血清Ⅰ型前胶原羧基端肽(PICP)Ⅰ型胶原羧基端肽β特殊序列(β-CTX)及血清总骨Ⅰ型前胶原氨基端延长肽(Total-PINP)];比较治疗后两组疼痛视觉模拟评分(VAS)、肿胀程度,比较两组骨折愈合时间;随访6个月后,比较两组肢体运动功能情况以及治疗期间药物不良反应及术后切口感染发生情况。结果:治疗后,研究组PICP及Total-PINP水平显著高于对照组(P<0.05),β-CTX水平显著低于对照组(P<0.05);治疗后,观察组VAS评分显著低于对照组(P<0.05),肢体周径差显著小于对照组(P<0.05),观察组骨折愈合时间显著短于对照组(P<0.05);随访6个月,末次随访时观察组上肢及下肢肢体运动功能评分较对照组更高(P<0.05);治疗期间两组无严重药物不良反应发生,两组术后切口感染发生率比较,差异无统计学意义(P>0.05)。结论:应用桃红四物汤加减辅助手术可明显改善四肢骨折患者术后骨代谢水平,缓解疼痛及肿胀症状,缩短骨折愈合时间,促进患者肢体功能恢复,有助于改善患者预后,且安全可靠。
Objective:Analyzing the influence of Modified Taohong Siwu Decoction with of assisting surgery on limb motor function,bone metabolism index and prognosis of patients with limb fracture after operation.Methods:A total of 96 patients with limb fractures admitted to the hospital from September 2019 to September 2020 were selected as the research objects,and the envelope method was used to randomly divide them into an observation group(48 cases)and a controlled group(48 cases).Both groups were treated with open reduction and internal fixation.The postoperative controlled group was treated with anti-infection and other conventional treatments.The observation group was treated with Taohong Siwu Decoction on the basis of the controlled group.Both groups were treated for 2 weeks.Comparison of bone metabolism indexes before and after treatment[serum type I procollagen carboxyl terminal peptide(PICP)type I collagen carboxy terminal peptideβspecial sequence(β-CTX)and serum total bone type I procollagen amino terminal elongation peptide(Total-PINP)].Compared the visual analogue scale(VAS)and swelling degree of the two groups after treatment,and compared the healing time of the two groups.Follow up for 6 months to compare the motor function of the two groups.Comparison of adverse drug reactions and postoperative wound infections in the two groups during treatment.Results:After treatment,the levels of PICP and Total-PINP in the study group were significantly higher than those in the controlled group(P<0.05),and the levels ofβ-CTX were significantly lower than those in the controlled group(P<0.05).After treatment,the observation group’s VAS score was significantly lower than that of the controlled group(P<0.05),and the limb circumference difference was significantly smaller than that of the controlled group(P<0.05).Follow-up for 6 months,the observation group’s fracture healing time was significantly shorter than that of the controlled group(P<0.05).Follow-up for 6 months,at the last follow-up,the upper and lower limb motor function scores of the observation group were higher than those of the controlled group(P<0.05).No serious adverse drug reactions occurred in the two groups during the treatment period,and there was no statistically significant difference in the incidence of postoperative incision infection between the two groups(P>0.05).Conclusion:The application of Taohong Siwu Decoction for assisting surgery can significantly improve postoperative bone metabolism in patients with limb fractures,relieve pain and swelling symptoms,shorten fracture healing time,promote the recovery of patients’limb function,help improve the prognosis of patients,and is safe and reliable.
作者
廖华
孙亚运
陈雪洁
LIAO Hua;SUN Yayun;CHEN Xuejie(Department of Orthopedics,Suining Municipal Hospital of Traditional Chinese Medicine,Suining Sichuan 629000,China)
出处
《四川中医》
2022年第11期140-144,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
四川省中医药管理局项目(项目编号:2020LC0223)
关键词
四肢骨折
桃红四物汤
肢体功能恢复
预后
Limb fractures
Taohong Siwu Decoction
Limb function recovery
Prognosis
作者简介
廖华,本科,副主任中医师,主要从事创伤骨科研究,Email:lh850988@163.com。
