摘要
目的:客观评价青蒿麻黄汤治疗社区获得性肺炎(CAP)痰热壅肺证的临床疗效。方法:选取2020年9月~2021年9月在我院进行治疗的116例CAP患者,按照随机数字表法分为对照组与观察组,各58例。对照组采用常规西医治疗,观察组基于对照组的基础上加用自拟方青蒿麻黄汤内服。比较两组临床总有效率;比较两组治疗前后炎症指标[白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)]、中医症候积分、两组临床指标(体温正常时间、肺部阴影褪去时间、咳嗽消失时间、住院时间);对比两组不良反应发生率。结果:治疗前,两组WBC、CRP、PCT水平差异比较均不具有统计学意义(P>0.05);治疗后,观察组临床总有效率高于对照组,WBC、CRP、PCT水平、中医证候积分均低于对照组,体温正常时间、肺部阴影褪去时间、咳嗽消失时间、住院时间均短于对照组,且差异具有统计学意义(P<0.05)。治疗后,观察组不良反应发生率低于对照组,但差异比较不具有统计学意义(P>0.05)。结论:青蒿麻黄汤治疗CAP痰热壅肺证疗效显著,且能减轻炎症反应,降低患者体温水平,缩短患者住院时间,安全性良好、值得临床推广应用。
Objective:To explore the clinical effect of using Qinghao Mahuang Decoction in the treatment of community-acquired pneumonia(CAP).Methods:A total of 116 patients with CAP treated in the hospital were enrolled between September 2020 and September 2021.According to random number table method,they were divided into a controlled group and an observation group,58 cases in each group.The controlled group was treated with routine western medicine,while the observation group was additionally treated with Qinghao Mahuang Decoction.The total clinical response rate,inflammatory indexes[white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT)],scores of TCM symptoms,clinical indexes(recovery time of body temperature,fade time of lung shadows,disappearance time of cough,hospitalization time)and the incidence of adverse reactions were compared between the two groups before and after treatment.Results:Before treatment,there was no significant difference in levels of WBC,CRP and PCT between the two groups(P>0.05).After treatment,total clinical response rate in the observation group was higher than that in the controlled group,levels of WBC,CRP and PCT,and scores of TCM syndromes were all lower than those in the controlled group,recovery time of body temperature,fade time of lung shadows,disappearance time of cough and hospitalization time were all shorter than those in the controlled group(P<0.05).After treatment,incidence of adverse reactions in the observation group was lower than that in the controlled group,but the difference was not statistically significant(P>0.05).Conclusion:Qinghao Mahuang Decoction can effectively treat CAP,relieve inflammatory response,lower body temperature and shorten hospitalization time,with good safety.
作者
陈其剑
吴悠
郑贵芝
张海燕
王浩凌
李冬琼
华志
CHEN Qijian;WU You;ZHENG Guizhi(Xichang Municipal People's Hospital,Xichang Sichuan 615000,China)
出处
《四川中医》
2023年第2期122-125,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
四川省中医药管理局中医药科研专项课题(编号:2021MS289,“青蒿麻黄汤”治疗社区获得性肺炎的临床研究)
关键词
社区获得性肺炎
炎症指标
青蒿麻黄汤
中医症候积分
临床研究
Community-acquired pneumonia
Inflammatory index
Qinghao Mahuang Decoction
Score of TCM symptom
Clinical study
