摘要
目的:观察安痫丸对卒中后癫痫(PSE)患者脑电图指标及认知功能的影响。方法:选取60例PSE患者随机分为治疗组(30例)和对照组(30例)。对照组予以丙戊酸钠缓释片口服,每次500mg,每日2次,治疗组在对照组基础上予以添加安痫丸口服,每次1丸,每日3次。两组患者均治疗12周,观察临床疗效及治疗前后脑电图活动情况、简易精神状态检查量表(MMSE)、美国国立卫生院脑卒中量表(NIHSS)评分变化情况,进行组间对比,并记录不良反应。结果:两组总有效率分别为93.33%、70.00%,差异具有统计学意义(P<0.05);治疗后两组患者的发作次数、每次发作的持续时间较治疗前均减少,改善的幅度治疗组较对照组明显(P<0.05);治疗后治疗组脑电图放电指数、涉及导联数改善明显高于对照组(P<0.05);两组患者脑电图α波相对功率较治疗前提高(P<0.05),β、θ、δ各频段功率均较治疗前下降(P<0.05),且治疗组变化优于对照组(P<0.05)。治疗组治疗后MMSE、NIHSS评分均较治疗前有所改善(P<0.01),对照组治疗后MMSE评分变化不明显(P>0.05)。结论:安痫丸添加治疗可改善卒中后癫痫患者脑电图指标,减轻癫痫发作,促进神经功能恢复及改善认知功能,无明显不良反应。
Objective:To observe the effect of Anxian Pill on EEG indexes and cognitive function in patients with poststroke epilepsy(PSE)。Methods:60 patients with PSE were randomly divided into treatment group(30 cases)and control group(30 cases).The control group was given sodium valproate sustained-release tablets orally,500mg each time,twice a day,while the treatment group was given Anxian pills orally,one pill each time,three times a day,on the basis of the control group.Both groups of patients were treated for 12 weeks,and the clinical efficacy,EEG activity before and after treatment,changes in the scores of the Simple Mental State Examination Scale(MMSE)and the National Institutes of Health Stroke Scale(NIHSS)were observed,comparison between groups were performed,and untoward effect were recorded.Results:The total effective rates of the two groups were 93.33%and 70.00%respectively,with statistically significant difference(P<0.05).After treatment,the number of seizures and the duration of seizures in the two groups decreased compared with those before treatment,and the improvement of the treatment group was significantly greater than that of the control group(P<0.05).After treatment,the EEG discharge index and the number of leads involved in the treatment group were significantly higher than those in the control group(P<0.05).EEG of two groups of patients theαwave power is higher than that before treatment(P<0.05),each frequency band power ofβ、θandδwave decreased compared with that before treatment(P<0.05),and the change of treatment group is better than control group(P<0.05).After treatment,the MMSE and NIHSS scores of treatment group improved compared with those before treatment(P<0.01),while the MMSE scores of control group didn’t change significantly after treatment(P>0.05).Conclusions:The addition treatment of Anxian Pill can improve the EEG indexes of epilepsy patients after stroke,alleviate seizures,improve cognitive function and promote the recovery of neurological function,without obvious adverse reactions.
作者
韩慧
张子环
李洪斌
张琳
吉丽
马超
于小洁
陈静
王颖
HAN Hui;ZHANG Zihuan;LI Hongbin(Beichen Hospital of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300400,China)
出处
《四川中医》
2023年第10期144-148,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
全国中医药创新骨干人才培训项目(国中医药办人教函<2019>91号)
天津市中医药管理局中医中西医结合科研项目(2021124)
天津市北辰区科委计划项目(编号:SHGY-2020052)
关键词
卒中后癫痫
中药治疗
脑电图指标
认知功能
Post-stroke epilepsy
Chinese medicine treatment
EEG index
Cognitive function
作者简介
通讯作者:王颖,副主任医师;韩慧,副主任医师,医学博士,E-mail:hanhui8042@163.com。
