摘要
目的:研究益胃除痞方联合雷贝拉唑钠肠溶胶囊治疗消化性溃疡的疗效并探讨其可能作用机制。方法:回顾性选取海南省中医院脾胃病科2020年8月~2022年6月收治的102例消化性溃疡患者为对象采用随机数字法分为两组。常规组61例给予雷贝拉唑钠肠溶胶囊治疗,益胃除痞组61例给予益胃除痞方联合雷贝拉唑钠肠溶胶囊治疗。治疗4周后评估两组疗效,检测两组血清炎症因子、三叶因子2(TFF2)、α-防御素(DEFA)等相关因子的水平,比较两组治疗前和治疗4周后中医症候评分、溃疡面积的差异。结果:益胃除痞组治疗4周后总有效率为94.12%(48/51),高于常规组的80.39%(41/51),有统计学差异(χ^(2)=4.320;P=0.038)。两组治疗4周后血管内皮细胞生长因子(VEGF)、TFF2、DEFA、超氧化物醋化酶(SOD)、碱性成纤维细胞生长因子(bFGF)水平高于治疗前,肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、白介素-8(IL-8)、白介素-17(IL-17)水平低于治疗前,且益胃除痞组治疗4周后炎症因子、MDA水平较常规组更低,TFF2、DEFA、VEGF、SOD、bFGF较常规组更高。两组治疗4周后中医症候评分、溃疡面积低于治疗前,且益胃除痞组治疗4周后较常规组更低(P<0.05)。结论:益胃除痞方联合雷贝拉唑肠溶胶囊治疗消化性溃疡可缩小溃疡面积,提高疗效,机制可能与抑制炎症反应,清除氧自由基,促进新生血管的形成有关。
Objective To study the therapeutic effect of Yiwei Chupi Formula combined with Rabeprazole sodium enteric coated capsule on peptic ulcer and explore its possible mechanism.Methods 102 patients with peptic ulcer admitted from August 2020 to June 2022 in the Department of Spleen and Gastroenterology of Hainan Hospital of Traditional Chinese Medicine were selected retrospectively and divided into two groups by random number method.61 cases in the routine group were treated with rabeprazole sodium enteric coated capsule,and 61 cases in the Yiwei Chupi group were treated with Yiwei Chupi Formula combined with rabeprazole sodium enteric coated capsule.After 4 weeks of treatment,evaluate the efficacy of the two groups,and detect the serum inflammatory factors,trefoil factor 2(TFF2)α-Defensin(DEFA)and other related factors were compared between the two groups before and after 4 weeks of treatment.Results After 4 weeks of treatment,the total effective rate in the group of benefiting stomach and removing abdominal distension was 94.12%(48/51),which was higher than 80.39%(41/51)in the conventional group,with statistical difference(χ2=4.320;P=0.038)。After 4 weeks of treatment,the levels of vascular endothelial growth factor(VEGF),TFF2,DEFA,superoxide acetate(SOD),basic fibroblast growth factor(bFGF)in both groups were higher than those before treatment,and tumor necrosis factor-α(TNF-α)、The levels of malondialdehyde(MDA),interleukin-8(IL-8)and interleukin-17(IL-17)were lower than those before treatment,and the levels of inflammatory factors and MDA were lower in the group of stomach benefiting and swelling removing after 4 weeks of treatment than those in the conventional group,while the levels of TFF2,DEFA,VEGF,SOD and bFGF were higher than those in the conventional group.After 4 weeks of treatment,the score of TCM symptoms and the area of ulcer in the two groups were lower than those before treatment,and after 4 weeks of treatment,it was lower in the stomach benefiting group than in the conventional group(P<0.05).Conclusion Yiwei Chupi Formula combined with rabeprazole enteric coated capsule can reduce the area of peptic ulcer and improve the curative effect.The mechanism may be related to inhibition of inflammatory reaction,elimination of oxygen free radicals and promotion of the formation of new blood vessels.
作者
卓利雄
曾微微
羊章凯
ZHUO Lixiong;ZENG Weiwei;YANG Zhangkai(Department of Spleen and Gastroenterology,Chinese Medicine Hospital of Hainan Province,Haikou Hainan 570216,China)
出处
《四川中医》
2023年第10期123-127,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
益胃除痞方
消化性溃疡
雷贝拉唑钠肠溶胶囊
氧自由基
炎症反应
Yiwei Chupi Recipe
Peptic ulcer
Rabeprazole sodium enteric coated capsules
Oxygen free radicals
Inflammatory response
