摘要
目的:探究益气养血活血法联合达格列净对糖尿病肾病患者肾小球滤过功能、血糖及一氧化氮(NO)/内皮素(ET)平衡的影响。方法:选取2020年1月至2022年6月我院收治的96例糖尿病肾病患者,按入院时间编号分为1~96号,奇数号为对照组,给予达格列净治疗,偶数号为联合组,在对照组基础上联合益气养血活血法治疗,比较两组疗效、中医证候积分、肾功能、血糖控制、NO水平、ET-1水平以及安全性。结果:治疗3个月后,联合组总有效率91.67%,高于对照组的75.00%(P<0.05);治疗3个月后,两组中医证候积分均降低,且联合组低于对照组(P<0.05);治疗2个月后、3个月后,联合组血肌酐、血尿素氮、尿微量白蛋白排泄率低于对照组(P<0.05),肾小球滤过率高于对照组(P<0.05);治疗2个月后、3个月后,联合组空腹血糖和餐后2小时血糖、糖化血红蛋白低于对照组(P<0.05);治疗1个月后、2个月后、3个月后,联合组NO高于对照组(P<0.05),ET-1低于对照组(P<0.05);两组并发症总发生率比较无明显差异(P>0.05)。结论:益气养血活血法联合达格列净治疗糖尿病肾病患者具有较高的临床疗效,可改善中医症状、肾小球滤过功能与血管内皮功能,提高血糖控制效果,且具有较高的安全性。
Objective:To explore the effects of Yiqi Yangxue Huoxue method combined with dapagliflozin on glomerular filtration function,blood glucose and nitric oxide(NO)/endothelin(ET)balance in patients with diabetic nephropathy.Methods:96 patients with diabetic nephropathy admitted to the hospital from January 2020 to June 2022 were selected and numbered from 1 to 96 according to the admission time.Patients with odd numbers were enrolled as control group and received dapagliflozin treatment,and patients with even numbers were included in combined group and were treated with Yiqi Yangxue Huoxue method on the basis of the control group.The efficacy,TCM syndromes scores,renal function,blood glucose control,NO level,ET-1 level and safety were compared between the two groups.Results:After 3 months of treatment,the total effective rate in combined group was 91.67%,which was higher than 75.00%in control group(P<0.05).The TCM syndromes scores in both groups after 3 months of treatment were decreased,and the scores in combined group were lower than those in control group(P<0.05).After 2 months and 3 months of treatment,serum creatinine,blood urea nitrogen and urinary microalbumin excretion rate were lower in combined group than those in control group(P<0.05)while the glomerular filtration rate was higher than that in control group(P<0.05).After 2 months and 3 months of treatment,the levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in combined group were lower compared with those in control group(P<0.05).After 1 month,2 months and 3 months of treatment,NO level in combined group was higher compared to control group(P<0.05)while ET-1 level was lower compared to control group(P<0.05).There was no significant difference in the total incidence rate of complications between the two groups(P>0.05).Conclusion:Yiqi Yangxue Huoxue method combined with dapagliflozin has a high clinical efficacy in the treatment of patients with diabetic nephropathy.It can improve the TCM symptom,glomerular filtration function and vascular endothelial function,and enhance the blood glucose control effect,and it has high safety.
作者
刘珊珊
张帆
孙丽丽
陈秀芝
杨真
LIU Shanshan;ZHANG Fan;SUN Lili(Department of Endocrinology,Taihe County Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine,Taihe Anhui236600,China)
出处
《四川中医》
2023年第10期131-136,共6页
Journal of Sichuan of Traditional Chinese Medicine
关键词
糖尿病肾病
达格列净
益气养血活血法
肾小球滤过功能
血管内皮功能
血糖控制
Diabetic nephropathy
Dapagliflozin
Yiqi Yangxue Huoxue method
Glomerular filtration function
Vascular endothelial function
Blood glucose control
