硫酸镁联合拉贝洛尔与硝苯地平治疗子痫前期患者的疗效及尿蛋白水平分析被引量：5

Analysis of the Efficacy and Urine Protein Level of Magnesium Sulfate Combined with Labetalol and Nifedipine in the Treatment of Preeclampsia

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摘要目的研究子痫前期患者采用硫酸镁联合拉贝洛尔与硝苯地平治疗的临床效果以及尿蛋白水平。方法该院选取2016年8月—2019年5月60例子痫前期患者,随机分为研究组(n=30)和参照组(n=30),其中硫酸镁联合拉贝洛尔治疗对象,定义为参照组,硫酸镁联合拉贝洛尔及硝苯地平治疗对象,定义为研究组。对疗效及尿蛋白水平变化予以观察。结果研究组总有效率为(96.67%),与参照组总有效率(73.33%)比较,差异有统计学意义(χ~2=6.405,P=0.011);治疗前,两组血压水平、24 h尿蛋白水平比较差异无统计学意义(t=0.229、0.383、0.410,P=0.820、0.703、0.683);治疗后,研究组血压水平、24 h尿蛋白水平有积极改善,优于参照组(t=6.986、8.183、5.707,P=0.000、0.000、0.000)。结论对子痫前期患者采用硫酸镁联合拉贝洛尔与硝苯地平治疗方案,治疗效果显著,值得推广。 Objective To investigate the clinical effects and urine protein levels of patients with preeclampsia treated with magnesium sulfate combined with labetalol and nifedipine.Methods We selected patients with pre-eclampsia from August 2016 to May 2019,and were randomly divided into study group(n=30)and reference group(n=30),in which magnesium sulfate combined with labetalol was treated.For the reference group,magnesium sulfate combined with labetalol and nifedipine were treated as the study group.The ef-fects and changes in urine protein levels were observed.Results The total effective rate of the study group was(96.67%),which was compared with the total effective rate of the reference group(73.33%),the difference was statistically significant(χ~2=6.405,P=0.011).There was no difference in blood pressure level and 24 h urine protein level between the two groups before treatment(t=0.229,0.383,0.410,P=0.820,0.703,0.683);after treatment,the blood pressure level and 24 h urinary protein level of the study group were positively improved,which was better than the reference group(t=6.986,8.183,5.707,P=0.000,0.000,0.000).Conclusion The treatment of patients with pre-eclampsia with magnesium sulfate combined with labetalol and nifedipine has a significant therapeutic effect and is worthy of promotion.

作者董自清 DONG Zi-qing(Department of Obstetrics,Lianyungang Maternal and Child Health Hospital,Lianyungang,Jiangsu Province,222000 China)

机构地区江苏省连云港市妇幼保健院产科

出处《世界复合医学》 2020年第1期181-183,共3页 World Journal of Complex Medicine

关键词硫酸镁拉贝洛尔硝苯地平子痫前期疗效尿蛋白水平 Magnesium sulfate Labetalol Nifedipine Preeclampsia Efficacy Urine protein levels

分类号 R714.244 [医药卫生—妇产科学]

作者简介董自清﹙1986-﹚,女,江苏连云港人,本科,主治医师,研究方向:产科相关疾病诊治。