摘要
血管性痴呆是临床第二大常见痴呆类型,以记忆力减退,认知功能下降为临床表现,患者生存质量差,治疗护理费用较高,给家庭和社会造成了沉重的负担。血管性痴呆,现代医学无明确推荐治疗用药,且疗效欠佳,中医的治未病思想和辨证论治的个体化治疗在防治血管性痴呆方面有着一定的优势,但目前尚无明确的中医相关诊断标准。临床预测模型符合当前个体化治疗和精准医学的思维模式,在临床及科研工作中扮演者重要角色。因此,建立血管性痴呆中西医结合临床预测模型将会对本病的预防和早期诊治提供帮助。本文从血管性痴呆的基本危险因素及临床预测模型的建立构想进行阐述,旨在论述和构想一个能够预测血管性痴呆的预测模型及建立条件,为临床工作者提供预防和治疗思路。
vascular dementia is the second most common type of dementia in clinical practice,mainly manifested by memory decline and cognitive function decline.Patients have poor quality of life and high cost of treatment and nursing,which has caused a heavy burden on families and society.Vascular dementia,modern medicine does not clearly recommend the treatment of drugs,and the effect is poor.The idea of preventing and treating diseases and individual treatment based on syndrome differentiation have obvious advantages in preventing and treating vascular dementia.Clinical prediction model conforms to the current thinking mode of precision medicine and plays an important role in clinical and scientific research.Therefore,the establishment of clinical prediction model of integrated traditional Chinese and western medicine for vascular dementia will be helpful for the prevention and early diagnosis and treatment of this disease.Based on the basic risk factors of vascular dementia and the conception of the clinical prediction model,this paper aims to discuss the establishment of a model and conditions that can predict vascular dementia,and provide ideas of prevention and treatment for clinical workers.
作者
宋博策
刘剑刚
李浩
Song Boce;Liu Jiangang;Li Hao(Beijing University of Chinese Medicine,Beijing 10029;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091;Institute of Cardiovascular Diseases,China Academy of Chinese Medical Sciences,Beijing 100091)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第5期1654-1661,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科学技术部国家“重大新药创制”科技重大专项(2009ZX09103—391):基于“虚-瘀-浊-毒”中医理论治疗认知障碍中药组分新配方一还脑益聪方的研究与开发,负责人:李浩
国家自然科学基金面上项目(30873338):基于“虚-瘀-浊-毒”病机基础的配伍中药对APP转基因小鼠痴呆模型早期干预研究,负责人:李浩
关键词
血管性痴呆
危险因素
中西医结合
临床预测模型
Vascular Dementia
Risk Factors
Integrated Traditional Chinese and Western Medicine
Clinical Prediction Model
作者简介
通讯作者:刘剑刚,研究员,研究生导师,主要研究方向:心血管病的中西医结合基础研究和临床研究;通讯作者:李浩,主任医师,博士研究生导师,主要研究方向:老年心脑血管疾病研究。
